Mechanical Communication at the Immunological Synapse.
Mechanical Communication at the Immunological Synapse.
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DOI：
10.1016/j.tcb.2016.10.005
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发表时间：
2017-04
影响因子：
19
通讯作者：
Huse M
中科院分区：
文献类型：
--
作者：
Basu R;Huse M
T 淋巴细胞和 B 淋巴细胞通过与抗原呈递靶细胞形成免疫突触进行通信。这些高度动态的接触的特点是连续的细胞骨架重塑事件，它不仅构建界面，而且还施加相当大的机械力。近年来，越来越清楚的是，突触力影响进出淋巴细胞的信息传递。在这里，我们回顾了目前对突触机制的理解，重点关注其作为细胞间通讯途径的作用。
T and B lymphocytes communicate by forming immunological synapses with antigen-presenting target cells. These highly dynamic contacts are characterized by continuous cytoskeletal remodeling events, which not only structure the interface but also exert a considerable amount of mechanical force. In recent years, it has become increasingly clear that synaptic forces influence information transfer both into and out of the lymphocyte. Here, we review our current understanding of synapse mechanics, focusing on its role as an avenue for intercellular communication.