Association of Oral Candidal Carriage with Dental Caries in Children
Association of Oral Candidal Carriage with Dental Caries in Children
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DOI：
10.1159/000314675
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发表时间：
2010-01-01
期刊：
影响因子：
4.2
通讯作者：
Ali, K.
中科院分区：
文献类型：
--
作者：
Raja, M.;Hannan, A.;Ali, K.
口腔念珠菌病是最常见的机会性口腔真菌感染之一。学龄儿童的口腔念珠菌携带是全世界日益关注的一个问题，最近与儿童龋齿发病率增加有关。目的：本研究旨在确定儿童口腔念珠菌携带与龋齿之间的关系。研究对象与方法：研究对象100名，年龄在6 ~ 12岁之间。受试者被平均分为两组，即研究组（龋齿阳性）和对照组（无龋齿）组。记录每位受试者的口腔卫生指数和DMFT/ DMFT评分。使用口腔内拭子和浓缩口腔冲洗液对念珠菌进行取样。以含0.1 mg/ml氯霉素的沙乌地葡萄糖琼脂为原代培养基。采用API-20C AUX和胚管形成试验对念珠菌进行鉴定。结果：龋阳性组口腔候选菌携带频率高于无龋组，差异有统计学意义（p < 0.01）。优势比为67.37，表明口腔念珠菌携带阳性的患者患龋风险较高（95% CI 14-323）。讨论：本研究结果强调念珠菌与龋齿的可能关联。结论：混合牙列儿童龋病的发生与口腔念珠菌携带频率呈正相关。版权所有：S. Karger AG，巴塞尔
Introduction: Oral candidiasis is one of the most common opportunistic oral fungal infections. Oral candidal carriage in schoolchildren is a subject of increasing interest worldwide and has recently been associated with increased caries incidence in children. Aims: This study was carried out to identify association between oral candidal carriage in children and dental caries. Subjects and Methods: One hundred subjects with an age range between 6 and 12 years were included in this study. The subjects were distributed equally into two groups, i.e., study (caries-positive) and control (caries-free) groups. Oral hygiene index and DMFT/dmft scores were recorded for each subject. Sampling for Candida was carried out using intraoral swabs and concentrated oral rinse. Sabouraud dextrose agar containing 0.1 mg/ml of chloramphenicol was used as the primary culture medium. Candida was identified by employing API-20C AUX and germ tube formation tests. Results: The subjects in the caries-positive group showed a high frequency of oral candidal carriage compared to the caries-free subjects and the results were statistically very significant (p < 0.01). The odds ratio was 67.37, implying a high caries risk with positive oral candidal carriage (95% CI 14-323). Discussion: The findings of this study underscore the possible association of Candida with dental caries. Conclusions: The occurrence of dental caries in children with mixed dentition is positively correlated with the frequency of oral candidal carriage. Copyright (C) 2010 S. Karger AG, Basel