EXPERIMENTAL SUB-RETINAL HEMORRHAGE IN RABBITS
EXPERIMENTAL SUB-RETINAL HEMORRHAGE IN RABBITS
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DOI：
10.1016/0002-9394(82)90301-4
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发表时间：
1982-01-01
影响因子：
4.2
通讯作者：
MACHEMER, R
中科院分区：
文献类型：
--
作者：
GLATT, H;MACHEMER, R
为了模拟人黄斑变性出血性脱离阶段，将新鲜自体血注入白化病兔视网膜下腔，并通过检眼镜、光学显微镜和电镜对这些视网膜进行临床研究。注射后1小时，视网膜变化极小，仅限于偶尔的感光细胞水肿。在第1天，存在感光细胞的显著损伤，其特征在于感光细胞的水肿和崩解以及外核层的固缩。有些光感受器由于血凝块的收缩或移动而脱离视网膜，或者两者兼而有之。到第7天，感光细胞几乎不存在。兔视网膜下出血24 h内造成不可逆的视网膜破坏。破坏上覆视网膜的机制可能由凝块的扩散屏障、凝块收缩对外节的机械损伤和铁毒性的组合组成。
To simulate the hemorrhagic detachment stage of disciform macular degeneration [in humans], fresh autologous blood was injected into the subretinal space of albino rabbits and these hemorrhages were studied clinically with the ophthalmoscope and by light microscopy and EM. One hour after injection, retinal changes were minimal and limited to occasional photoreceptor edema. At 1 day, there was marked damage of the photoreceptor cells characterized by edema and disintegration of the photoreceptors and pyknosis of the outer nuclear layer. Some photoreceptors had been pulled off the retina by contraction or movement of the blood clot, or both. By 7 days, the photoreceptor cells were almost absent. Subretinal hemorrhage in rabbits led to irreversible retinal destruction within 24 h. The mechanism for destruction of the overlying retina probably consists of a combination of a diffusion barrier by the clot, mechanical damage to the outer segments by contraction of the clot and Fe toxicity.