Cell population dynamics of periodontal ligament stimulated with parathyroid extract.
Cell population dynamics of periodontal ligament stimulated with parathyroid extract.
复制标题
用甲状旁腺提取物刺激牙周膜的细胞群动态。
DOI：
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发表时间：
1975
影响因子：
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通讯作者：
W. E. Roberts
中科院分区：
文献类型：
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作者：
W. E. Roberts
年轻成年大鼠注射甲状旁腺提取物（PTE）。与先前吸收的牙槽骨表面相邻的牙周韧带（PDL）被分为从骨到牙骨质的四个区域，编号为I至IV。 I 区和 IV 区分别位于骨和牙骨质表面 25 mmu 以内，而 PDL 中心的平分线将 II 区和 III 区分开。在 PTE 给药后的前 5 小时内，观察到所有区域的核总数净增加约 16 个。由于局部有丝分裂不超过两个细胞核，因此大约 14 个细胞明显迁移到该区域。在最初的 5 小时内，I 区和 II 区总共增加了 21 个细胞，显然是迁移到该区域的细胞的唯一接收者 (14)，另外还有来自 III 区的大约 7 个细胞，在此期间丢失了细胞。在 II 区同时进行的组织学观察显示，在前 5 小时内血管内单核细胞和血管周围巨噬细胞增加，表明细胞通过血管通道迁移到 II 区。数据表明，与受刺激的破骨细胞组织发生相关的 PDL 细胞结构增加有两个来源：(1) 局部 PDL 细胞增殖和 (2) PTE 后前 5 小时内迁移细胞的流入（可能通过血管通道）。
Young adult rats were injected with parathyroid extract (PTE). Periodontal ligament (PDL) adjacent to a previously resorbing alveolar bone surface was divided into four zones number I to IV, from bone to cementum. Zones I and IV were within 25 mmu of the bone and cementum surfaces, respectively, while a line bisecting the center of the PDL separated Zones II and III. A net increase of about 16 total nuclei in all zones was observed during the first five hours after PTE administration. Since local mitosis accounted for no more than two nuclei, approximately 14 cells apparently migrated into the area. Over the first five hours Zones I and II combined showed a 21-cell increase, being apparently the sole recipients of cells migrating into the field (14) plus approximately seven more from Zone III, which lost cells during the time period. The concurrent histological observation in Zone II, of increased intravascular monocytes and perivascular macrophages during the first five hours, suggests cells are migrating into Zone II via vascular channels. The data suggest two sources for increased PDL cellularity associated with stimulated osteoclast histogenesis: (1) local PDL cellular proliferation and (2) influx of migrating cells (probably through vascular channels) during first five hours after PTE.