Barriers and strategies to achieve a cure for HIV.
Barriers and strategies to achieve a cure for HIV.
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DOI：
10.1016/s2352-3018(18)30039-0
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发表时间：
2018-06
期刊：
影响因子：
--
通讯作者：
Lewin SR
中科院分区：
文献类型：
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作者：
Pitman MC;Lau JSY;McMahon JH;Lewin SR
在使用CCR5Δ32干细胞移植治愈艾滋病毒的报道九年后，尽管进行了大量的科学努力，但没有进一步证实艾滋病毒治愈的病例。然而，在了解潜伏艾滋病毒宿主的生物学以及使用日益复杂的工具测量抗逆转录病毒治疗（ART）中持续存在的病毒量方面取得了重大进展。这方面的知识正在转化为越来越长的临床试验管道，寻求减少病毒的持续性参与抑制性ART，并最终允许安全停止ART。在这里，我们审查的主要障碍，艾滋病毒治愈，方法来衡量艾滋病毒的持续性ART和临床策略，正在评估治愈艾滋病毒。最后，我们强调了该领域的未来发展方向。
Nine years following the report of a cure for HIV using CCR5Δ32 stem cell transplantation, there have been no further cases of confirmed HIV cure despite much scientific effort. However, significant progress has been made in understanding the biology of the latent HIV reservoir and in measuring the amount of virus that persists on antiretroviral therapy (ART) using increasingly sophisticated tools. This knowledge is being translated into an increasingly long pipeline of clinical trials seeking to reduce viral persistence in participants on suppressive ART and ultimately to allow safe cessation of ART. Here we review the main barriers to HIV cure, methods to measure HIV persistence on ART and clinical strategies that are under evaluation to cure HIV. Finally, we highlight future directions for the field.