Aspects of adaptive host response in periodontitis
Aspects of adaptive host response in periodontitis
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DOI：
10.1111/j.1600-051x.2005.00820.x
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发表时间：
2005-01-01
影响因子：
6.7
通讯作者：
Donati, M
中科院分区：
文献类型：
--
作者：
Berglundh, T;Donati, M
目的：从牙周炎的细胞组成、T细胞受体（TCR）基因表达、辅助性T细胞（Th）细胞因子谱和自身免疫成分等方面综述牙周炎的宿主反应（活组织检查、龈沟液、牙周炎受试者的血液）。在牙周炎病变中，浆细胞是最常见的细胞类型，占所有细胞的约50%，而B细胞占约18%。B细胞的比例大于T细胞的比例，Th细胞的数量大于T细胞毒性细胞。多形细胞和巨噬细胞的比例小于所有细胞的5%。侵袭性牙周炎和慢性牙周炎的病变表现出相似的细胞组成。然而，疾病严重程度的差异可能反映了浆细胞和B细胞密度的增加。B细胞是牙周炎中重要的抗原提呈细胞。牙周炎病变表达一个独特的TCR基因库，这是不同于血液中。超抗原在牙周炎中的作用尚不清楚。关于牙周炎中Th-1和Th-2细胞的比较设计和无偏定量方法的研究很少。牙周炎病变中B细胞和浆细胞的相对优势不能完全用Th-2功能的增强来解释，而可能是因为Th-1和Th-2之间的失衡。自身免疫反应在牙周炎病变中是明显的。然而，自身抗体在牙周炎宿主反应调节中的作用还有待进一步阐明。自身反应性B细胞在牙周炎患者中的比例高于健康对照者。
Objective: To review host response in periodontitis with respect to cellular composition of lesions, T cell receptor (TCR) gene expression, cytokine profiles of T-helper (Th) cells and autoimmune components.Material and methods: The studies included were confined to human material (biopsies, gingival crevicular fluid, blood from subjects with periodontitis).Results and conclusions: In periodontitis lesions, plasma cells are the most common cell type and represent about 50% of all cells, while B cells comprise about 18%. The proportion of B cells is larger than that of T cells and Th cells occur in larger numbers than T cytotoxic cells. Polymorphonuclear cells and macrophages are found in fractions of less than 5% of all cells. Lesions in aggressive and chronic forms of periodontitis exhibit similar cellular composition. Differences in disease severity, however, may reflect increases in plasma cell and B cell densities. B cells serve as important antigen-presenting cells in periodontitis. The periodontitis lesion expresses a unique TCR gene repertoire that is different from that in blood. The role of superantigens in periodontitis is unclear. There are few studies using comparative designs and unbiased quantitative methods regarding Th-1 and Th-2 cells in periodontitis. The relative dominance of B cells and plasma cells in periodontitis lesions cannot entirely be explained by enhanced Th-2 functions but maybe because of an imbalance between Th-1 and Th-2. Autoimmune reactions are evident in periodontitis lesions. The role of auto-antibodies in the regulation of host response in periodontitis, however, needs to be clarified. Auto-reactive B cells occur in larger proportions in subjects with periodontitis than in healthy controls.