Metabolic control of transcription.
Metabolic control of transcription.
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转录的代谢控制。
DOI：
10.1126/science.adi7577
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Taylor,EricB
中科院分区：
文献类型：
--
作者：
Taylor,EricB
将环境刺激与生物体转录反应联系起来的机制有助于适应和生存。由于光通过光合作用发出能量信号，因此光是植物最重要的环境信号之一。在本期第179页，Huanget al.证明，在植物拟南芥中，光照刺激染色质局部消耗三羧酸（TCA）循环代谢物α-酮戊二酸，通过损害核小体组蛋白尾部的去甲基化来协调全局基因表达。这些发现提供了一种分子机制来解释黑腹果蝇基因组如何感知光线。他们还展示了亚细胞代谢如何在空间上重组以调节染色质结构和转录。
Mechanisms that link environmental stimuli to organismal transcriptional responses facilitate adaptation and survival. Because it signals energy availability through photosynthesis, light is among the most important environmental signals for plants. On page 179 of this issue, Huanget al.demonstrate that, in the plantArabidopsis thaliana, light exposure stimulates chromatin-local depletion of the tricarboxylic acid (TCA) cycle metabolite α-ketoglutarate to orchestrate global gene expression by impairing demethylation of nucleosomal histone tails. These findings provide a molecular mechanism for how theArabidopsisgenome senses light. They also demonstrate how subcellular metabolism can be spatially reorganized to regulate chromatin structure and transcription.