Conversion of MCI to dementia: Role of proton magnetic resonance spectroscopy
Conversion of MCI to dementia: Role of proton magnetic resonance spectroscopy
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DOI：
10.1016/j.neurobiolaging.2005.05.002
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发表时间：
2006-07-01
影响因子：
4.2
通讯作者：
Mecocci, Patrizia
中科院分区：
文献类型：
--
作者：
Metastasio, Antonio;Rinaldi, Patrizia;Mecocci, Patrizia
轻度认知功能障碍（MCI）是一组具有痴呆高风险的认知障碍。遗忘亚型（amnestic subtype，aMCI）可能是阿尔茨海默病（Alzheimer's disease，AD）的前驱状态。本研究的目的是通过质子磁共振波谱（H-1 MRS）鉴定脑代谢物的修饰，从而能够检测有向AD转化风险的aMCI受试者。25例aMCI患者和29例正常老年人入组;他们接受了全面的临床和仪器评估，大脑H-1 MRS扫描，以测量双侧三角区旁白色物质中的N-乙酰天冬氨酸（NAA）、胆碱（Cho）、肌醇（mI）和肌酸（Cr）。1年后，5例MCI受试者变为痴呆（进行性MCI，pMCI）。将其代谢物的基线水平与稳定型MCI（sMCI）和对照组中评估的水平进行比较。我们在左半球观察到pMCI（1.48 +/- 0.08）和sMCI（1.65 +/- 0.12）之间以及pMCI和对照组（1.63 +/- 0.16）之间的NAA/Cr比率的显著差异，表明这种代谢改变可以在痴呆临床表现之前检测到。(c)2005年爱思唯尔公司All rights reserved.
Mild cognitive impairment (MCI) represents a heterogeneous croup of cognitive disturbances at high risk of dementia. The amnestic subtype (aMCI) might be a prodromal state of Alzheimer's disease (AD). The aim of this study is the identification, by proton magnetic resonance spectroscopy (H-1 MRS), of modifications in brain metabolites able to detect subjects with aMCI at risk of conversion towards AD. Twenty-five subjects with aMCI and 29 normal elderly were enrolled; they underwent a comprehensive clinical and instrumental assessment, a cerebral H-1 MRS scan to measure N-acetyl aspartate (NAA), choline (Cho), myo-inositol (mI) and creatine (Cr) in the paratrigonal white matter, bilaterally. After 1 year, 5 MCI subjects became demented (progressive MCI, pMCI). Their baseline levels of metabolites were compared with those evaluated in stable MCI (sMCI) and in controls. We observed a significant difference of the NAA/Cr ratio between pMCI (1.48 +/- 0.08) and sMCI (1.65 +/- 0.12) and between pMCI and controls (1.63 +/- 0.16) in the left hemisphere, suggesting that this metabolic alteration can be detected before the clinical appearance of dementia. (c) 2005 Elsevier Inc. All rights reserved.