Toddlers later diagnosed with autism exhibit multiple structural abnormalities in temporal corpus callosum fibers
Toddlers later diagnosed with autism exhibit multiple structural abnormalities in temporal corpus callosum fibers
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DOI：
10.1016/j.cortex.2016.12.024
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发表时间：
2017-12-01
期刊：
影响因子：
3.6
通讯作者：
Courchesne, Eric
中科院分区：
文献类型：
--
作者：
Fingher, Noa;Dinstein, Ilan;Courchesne, Eric
Interhemispheric functional connectivity abnormalities are often reported in autism and it is thus not surprising that structural defects of the corpus callosum (CC) are consistently found using both traditional MRI and DTI techniques. Past DTI studies however, have subdivided the CC into 2 or 3 segments without regard for where fibers may project to within the cortex, thus placing limitations on our ability to understand the nature, timing and neurobehavioral impact of early CC abnormalities in autism. Leveraging a unique cohort of 97 toddlers (68 autism; 29 typical) we utilized a novel technique that identified seven CC tracts according to their cortical projections. Results revealed that younger (
