New role for the (pro)renin receptor in T-cell development
New role for the (pro)renin receptor in T-cell development
复制标题
DOI：
10.1182/blood-2015-03-635292
复制
发表时间：
2015-07-23
期刊：
影响因子：
20.3
通讯作者：
Binger, Katrina J.
中科院分区：
文献类型：
--
作者：
Geisberger, Sabrina;Maschke, Ulrike;Binger, Katrina J.
The (pro)renin receptor (PRR) was originally thought to be important for regulating blood pressure via the renin-angiotensin system. However, it is now emerging that PRR has instead a generic role in cellular development. Here, we have specifically deleted PRR from T cells. T-cell-specific PRR-knockout mice had a significant decrease in thymic cellularity, corresponding with a 100-fold decrease in the number of CD4(+) and CD8(+) thymocytes, and a large increase in double-negative (DN) precursors. Gene expression analysis on sorted DN3 thymocytes indicated that PRR-deficient thymocytes have perturbations in key cellular pathways essential at the DN3 stage, including transcription and translation. Further characterization of DN T-cell progenitors leads us to propose that PRR deletion affects thymocyte survival and development at multiple stages; from DN3 through to DN4, double-positive, and single-positive CD4 and CD8. Our study thus identifies a new role for PRR in T-cell development.
