Intensity of antigen expression reflects IGHV mutational status and Dohner-defined prognostic categories in chronic lymphocytic leukemia, monoclonal B-cell lymphocytosis, and small lymphocytic lymphoma.
Intensity of antigen expression reflects IGHV mutational status and Dohner-defined prognostic categories in chronic lymphocytic leukemia, monoclonal B-cell lymphocytosis, and small lymphocytic lymphoma.
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DOI：
10.1080/10428194.2021.1894641
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发表时间：
2021-08
影响因子：
2.6
通讯作者：
中科院分区：
文献类型：
--
作者：
我们证明了抗原定量在慢性淋巴细胞白血病/小淋巴细胞淋巴瘤（CLL/SLL）和单克隆B细胞淋巴细胞增多症（MBL）中的预后效用。通过流式细胞术测定CLL（185/208）、SLL（8/208）和MBL（15/208）病例中CD 20、CD 22、CD 25、CD 19和%CD38（+）的中位抗体结合/细胞（ABC），然后与Dohner分类、免疫球蛋白状态（突变，IGHV-M;未突变，IGHV-U）、CLL-IPI风险和至首次治疗时间（TTFT）进行比较。12例三体性病例显示%CD38表达增加（p=0.0379）。在IGHV-U中观察到的%CD38高于IGHV-M（p=0.0003）。IGHV-U与IGHV-M相比，CD 20 ABC增加（p=0.006）。Del 13 q病例显示较低的CD 22 ABC（p=0.0198）。无细胞遗传学异常的病例显示较高的CD 19 ABC（p=0.0295）和CD 22 ABC（p=0.0078）。Del 17 p病例显示较低的CD 25 ABC（p=0.0097）。高和极高CLL-IPI风险组与高CD 38表达（p=0.02）和低CD 25 ABC（p=0.0004）相关。TTFT缩短与高CD 38表达相关（p<0.0001）。有趣的是，高CD 25 ABC倾向于缩短TTFT（p=0.07）。定量抗原表达反映CLL-IPI风险组和Dohner分类。
We demonstrate the prognostic utility of antigen quantitation in chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) and monoclonal B-cell lymphocytosis (MBL). Median antibody-bound-per-cell (ABC) of CD20, CD22, CD25, CD19, and %CD38(+) was determined in CLL (185/208), SLL (8/208) and MBL (15/208) cases by flow cytometry, then compared to Dohner-classification, immunoglobulin status (mutated, IGHV-M; unmutated, IGHV-U), CLL-IPI risk and time to first treatment (TTFT). Trisomy 12 cases showed increased %CD38-expression (p=0.0379). Higher %CD38 was observed in IGHV-U versus IGHV-M (p=0.0003). CD20ABC was increased in IGHV-U versus IGHV-M (p=0.006). Del13q cases demonstrated lower CD22ABC (p=0.0198). Cases without cytogenetic abnormality exhibited higher CD19ABC (p=0.0295) and CD22ABC (p=0.0078). Del17p cases demonstrated lower CD25ABC (p=0.0097). High and very-high CLL-IPI risk groups were associated with high CD38-expression (p=0.02) and low CD25ABC (p=0.0004). Shortened TTFT was associated with high CD38-expression (p<0.0001). Interestingly, high CD25ABC trended towards shortened TTFT (p=0.07). Quantitative antigen expression reflects CLL-IPI risk groups and Dohner-classification.
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影响因子：
3.4
作者：
Jasper, Gregory A.;Arun, Indu;Stetler-Stevenson, Maryalice
通讯作者：
Stetler-Stevenson, Maryalice
影响因子：
20.3
作者：
Ghia, P;Guida, G;Caligaris-Cappio, F
通讯作者：
Caligaris-Cappio, F
影响因子：
11.4
作者：
Hulkkonen, J;Vilpo, L;Vilpo, J
通讯作者：
Vilpo, J
影响因子：
6.5
作者：
Matutes, E;Oscier, D;Catovsky, D
通讯作者：
Catovsky, D
影响因子：
20.3
作者：
RAI, KR;SAWITSKY, A;PASTERNACK, BS
通讯作者：
PASTERNACK, BS