Differential Immunogenicity of A Recombinant Hepatitis B Vaccine in Iranian Neonates: Influence of Ethnicity and Environmental Factors
Differential Immunogenicity of A Recombinant Hepatitis B Vaccine in Iranian Neonates: Influence of Ethnicity and Environmental Factors
复制标题
重组乙型肝炎疫苗在伊朗新生儿中的差异免疫原性：种族和环境因素的影响
DOI：
--
复制
发表时间：
2004
期刊：
影响因子：
--
通讯作者：
J. Khoshnoudi
中科院分区：
文献类型：
--
作者：
A. Jafarzadeh;F. Shokri;S. M. Hazrati;S. Ghorbani;B. Mazaheri;J. Khoshnoudi
目的：比较重组B型肝炎（HB）疫苗在伊朗两个不同地理和种族背景城市出生的两组新生儿中的免疫原性。材料与方法：在田间条件下，以0、1.5和9个月的间隔向伊朗健康新生儿接种10微克重组乙肝疫苗。受试者包括两组290和231名新生儿，分别来自伊朗西北部（乌尔米耶）和东南部（克尔曼）的两个城市。在最后一剂疫苗接种后2-4周，通过夹心ELISA定量血清中的抗-HBs抗体水平。结果如下：乌尔米耶市新生儿抗-HBs> 10 IU/L的保护率（98.3%）和血清抗- HBs抗体滴度（11869比6104 IU/L）均显著高于克尔曼市新生儿（P<0.001）。结论：种族和/或环境因素在重组乙肝疫苗免疫应答中起重要作用。
Objective: To compare immunogenicity of a recombinant hepatitis B (HB) vaccine in two groups of neonates born in two cities of Iran with different geographic and ethnic backgrounds. Materials and Methods: Ten micrograms of a recombinant HB vaccine was administered under field condition to Iranian healthy neonates at 0, 1.5 and 9 months intervals. The subjects consisted of two groups of 290 and 231 neonates selected from two cities located at north-west (Urmia) and south-east (Kerman) of Iran, respectively. The level of anti-HBs antibody was quantitated in serum 2-4 weeks after administration of the last vaccine dose, by sandwich ELISA. Results: A higher seroprotection rate (anti-HBs> 10 IU/L) (98.3% vs. 96.1%) and significantly increased serum anti- HBs antibody titer (11869 vs. 6104 IU/L) (P<0.001) were induced in vaccinated neonates from Urmia city, compared to those born in Kerman. Conclusion: These findings suggest contribution of ethnic and/or environmental factors in the antibody response to recombinant HB vaccine in human.