Cyclic estradiol treatment enhances the effects of interleukin-1beta on food intake in female rats.
Cyclic estradiol treatment enhances the effects of interleukin-1beta on food intake in female rats.
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环雌二醇治疗增强了白细胞介素-1β对雌性大鼠食物摄入的影响。
DOI：
10.1006/brbi.2001.0621
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
Roberto,Francesca
中科院分区：
文献类型：
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作者：
Butera,PeterC;Doerflinger,AliciaL;Roberto,Francesca
促炎细胞因子引起行为和生理反应，包括食物摄入减少、发烧和对日常活动普遍不感兴趣。卵巢激素调节雌性哺乳动物的免疫系统活动和对细胞因子的反应，这表明免疫功能的性别差异可能受到性腺类固醇的影响。在该实验中，雌性成年大鼠被切除卵巢，并在术后3周每天两次皮下注射5.0或20.0μg苯甲酸雌二醇或油载体。经过 2 天的激素治疗后，动物在光照抵消前 1 小时接受腹腔注射白细胞介素 1β (IL-1β) 或盐水。光偏移后2小时测量食物和水的摄入量。结果表明，雌二醇治疗的循环模式增强了 IL-1β 的厌食作用，并表明对免疫系统激活的反应受到雌二醇的影响。
Proinflammatory cytokines elicit behavioral and physiological responses that include decreased food intake, fever, and a general disinterest in usual activities. Ovarian hormones modulate immune system activity and responsiveness to cytokines in female mammals, suggesting that sex differences in immune function may be influenced by gonadal steroids. In this experiment, female adult rats were ovariectomized and given two daily subcutaneous injections of 5.0 or 20.0 μg of estradiol benzoate or the oil vehicle 3 weeks after surgery. Following 2 days of hormone treatment, animals received ip injections of interleukin-1β (IL-1β) or saline 1 h before light offset. Food and water intake was measured 2 h after light offset. The results indicate that a cyclic pattern of estradiol treatment enhances the anorectic effect of IL-1β and suggest that responses to immune system activation are influenced by estradiol.