Association between mannan binding protein deficiency and recurrent miscarriage
Association between mannan binding protein deficiency and recurrent miscarriage
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甘露聚糖结合蛋白缺乏与复发性流产之间的关联
DOI：
10.1093/oxfordjournals.humrep.a136330
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发表时间：
1995
影响因子：
6.1
通讯作者：
W. Liston
中科院分区：
文献类型：
--
作者：
D. Kilpatrick;B. H. Bevan;W. Liston
通过酶联免疫吸附测定测定献血者血清中甘露聚糖结合蛋白（MBP）的分布，以确定正常浓度。在经历反复流产的夫妇中，16%（135 人中的 21 人）的女性伴侣和 14%（108 人中的 15 人）的男性伴侣 MBP 浓度异常低，而产科正常对照组的这一比例低于 5%（P < 0.005）。当仅考虑假定为导致 MBP 缺乏的突变等位基因纯合的受试者时，这种关系甚至更强（9.5% 与 1.0%）且更显着（P < 0.002）。通过免疫组织化学，可以在早孕期胎盘中证实 MBP。我们认为，胎儿胎盘单位内低浓度的 MBP 会增加胎儿流产的易感性，这可能是通过感染引起的胎盘细胞因子失衡所致。
The distribution of mannan binding protein (MBP) in blood donor sera was determined by enzyme-linked immunosorbent assay to establish normal concentrations. Abnormally low MBP concentrations were found in 16% (21 out of 135) of female partners and 14% (15 out of 108) of male partners of couples experiencing recurrent miscarriage, compared with < 5% of obstetrically normal controls (P < 0.005). This relationship was even stronger (9.5 versus 1.0%) and more significant (P < 0.002) when only subjects presumed to be homozygous for the mutant allele responsible for MBP deficiency were considered. By immunohistochemistry, MBP could be demonstrated in first trimester placenta. We suggest that low concentrations of MBP within the feto-placental unit increase susceptibility to fetal loss, possibly via an infection-induced placental cytokine imbalance.