Functions of kinesin superfamily proteins in neuroreceptor trafficking.
Functions of kinesin superfamily proteins in neuroreceptor trafficking.
复制标题
驱动蛋白超家族蛋白在神经受体运输中的功能。
DOI：
10.1155/2015/639301
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发表时间：
2015
影响因子：
--
通讯作者：
Xu J
中科院分区：
文献类型：
--
作者：
Wang N;Xu J
突触可塑性被广泛认为是学习和记忆的细胞基础。了解突触可塑性的分子机制已经是神经科学研究的中心之一超过三十年。α-氨基-3-羟基-5-甲基异恶唑啉-4-丙酸（AMPA-）型和N-甲基-D-天冬氨酸（NMDA-）型谷氨酸受体在突触中的转运是许多突触可塑性的关键分子事件。红藻氨酸受体是另一种类型的谷氨酸受体，在突触传递中发挥重要作用。此外，GABA受体在调节突触可塑性方面也起重要作用。驱动蛋白超家族蛋白（也称为KIF）通过与不同衔接蛋白的相互作用在顺行和逆行方向上运输各种货物。最近的研究表明，KIFs调节NMDA受体，AMPA受体，红藻氨酸受体和GABA受体的运输，因此在神经元活动中发挥重要作用。本文就KIFs在神经受体转运和突触可塑性中的重要作用作一综述。
Synaptic plasticity is widely regarded as the cellular basis of learning and memory. Understanding the molecular mechanism of synaptic plasticity has been one of center pieces of neuroscience research for more than three decades. It has been well known that the trafficking of α-amino-3-hydroxy-5-methylisoxazoloe-4-propionic acid- (AMPA-) type, N-methyl-D-aspartate- (NMDA-) type glutamate receptors to and from synapses is a key molecular event underlying many forms of synaptic plasticity. Kainate receptors are another type of glutamate receptors playing important roles in synaptic transmission. In addition, GABA receptors also play important roles in modulating the synaptic plasticity. Kinesin superfamily proteins (also known as KIFs) transport various cargos in both anterograde and retrograde directions through the interaction with different adaptor proteins. Recent studies indicate that KIFs regulate the trafficking of NMDA receptors, AMPA receptors, kainate receptors, and GABA receptors and thus play important roles in neuronal activity. Here we review the essential functions of KIFs in the trafficking of neuroreceptor and synaptic plasticity.
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影响因子：
25
作者：
Hoogenraad, CC;Milstein, AD;Sheng, M
通讯作者：
Sheng, M
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作者：
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通讯作者：
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通讯作者：
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64.8
作者：
DAVIES, CH;STARKEY, SJ;COLLINGRIDGE, GL
通讯作者：
COLLINGRIDGE, GL