Comparison of Procalcitonin and C-Reactive Protein Tests in Children with Urinary tract infection
Comparison of Procalcitonin and C-Reactive Protein Tests in Children with Urinary tract infection
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尿路感染儿童降钙素原和C反应蛋白检测的比较
DOI：
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发表时间：
2009
期刊：
影响因子：
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通讯作者：
F. Salimi
中科院分区：
文献类型：
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作者：
P. Ayazi;A. Mahyar;H. Hashemi;M. Daneshi;Toktam Karimzadeh;F. Salimi
目的：尿路感染（UTI）是儿童常见病。儿童上尿路感染和下尿路感染的区别有一些不明确的地方。本研究的目的是确定降钙素原（PCT）与C反应蛋白（CRP）在预测肾脏受累方面的敏感性、特异性、阳性预测值（PPV）和阴性预测值（NPV）。方法：测定111例尿路感染患儿血中PCT和CRP的浓度。采用99mTc -二巯基琥珀酸（DMSA）显像评估肾实质受累情况。测定敏感性、特异性、PPV和NPV。结果：111例患儿中，52例（46.8%）表现为急性肾脏受累，23例（20.7%）尿路感染较低，36例（32.5%）拒绝DMSA肾脏扫描检查。上尿路感染36例（69.2%），下尿路感染12例（52.2%）PCT阳性。PCT和CRP的敏感性、特异性、PPV和NPV分别为70.6、45.5、75.5、40%和96.2、4.3、69.4和33.3%。结论：肾实质受累与血清PCT、CRP水平无明显相关性。然而，结果表明，与CRP相比，PCT是一个更好的诊断测试。
Objective: U rinary tract infection (UTI) is a common disease in children. T he distinction between upper and lower UTI in children is associated with some ambiguities. The objective of this study was to determine the sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of procalcitonin (PCT) compared to C‐reactive protein (CRP) in predicting renal involvement. Methods: Serum concentrations of PCT and CRP in blood samples of 111 children with UTI were measured. Renal parenchymal involvement was evaluated with 99mTc‐ dimercaptosuccinic acid (DMSA) scintigraphy. Sensitivity, specificity, PPV and NPV were determined. Findings: Out of 111 children, 52 (46.8%) were shown to have acute renal involvement, 23 (20.7%) lower UTI, and 36 (32.5%) refused to be examined by DMSA renal scan. PCT was positive in 36 (69.2%) patients with upper UTI and 12 (52.2%) with lower UTI. The sensitivity, specificity, PPV and NPV obtained for PCT and CRP were 70.6, 45.5, 75, 40% and 96.2, 4.3, 69.4, and 33.3%, respectively. Conclusion: No significant correlation was found between renal parenchymal involvement and serum levels of PCT and CRP. However, the results demonstrated that the PCT was a better diagnostic test compared to CRP.