Real-time shear-wave elastography: Applicability, reliability and accuracy for clinically significant portal hypertension
Real-time shear-wave elastography: Applicability, reliability and accuracy for clinically significant portal hypertension
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DOI：
10.1016/j.jhep.2014.12.007
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发表时间：
2015-05-01
影响因子：
25.7
通讯作者：
Bosch, Jaime
中科院分区：
文献类型：
--
作者：
Procopet, Bogdan;Berzigotti, Annalisa;Bosch, Jaime
背景和目标：实时剪切波弹性成像（RT-SWE）可能是有用的，以评估门静脉高压症的严重程度，测量的可靠性标准是needed.Methods：我们前瞻性地包括88例连续肝静脉压力梯度测量（HVPG，参考标准）门静脉高压症。通过RT-SWE和瞬时弹性成像（TE）测量肝硬度（LS）。用RT-SWE法测定脾脏硬度（SS）。RT-SWE的可靠性标准进行了搜索，这些技术的准确性，以确定HVPG P10毫米汞柱（临床上显着的门静脉高压症，CSPH）进行了测试和内部验证的bootstrapping analysis.Results：LS和SS RT-SWE是可行的，分别在87（99%）和58（66%）的患者。两者均与HVPG相关（LS：R = 0.611，p < 0.0001和SS：R = 0.514，p < 0.0001）。LS诊断CSPH表现良好（乐观校正AUROC = 0.858）。测量的可靠性受标准差（SD）/中位数比和深度的影响。SD/中位数
Background & Aims: Real-time shear wave elastography (RT-SWE) might be useful to assess the severity of portal hypertension; reliability criteria for measurement are needed.Methods: We prospectively included 88 consecutive patients undergoing hepatic venous pressure gradient measurement (HVPG, reference standard) for portal hypertension. Liver stiffness (LS) was measured by RT-SWE and by transient elastography (TE). Spleen stiffness (SS) was measured by RT-SWE. Reliability criteria for RT-SWE were searched, and the accuracy of these techniques to identify HVPG P10 mmHg (clinically significant portal hypertension, CSPH) was tested and internally validated by bootstrapping analysis.Results: LS and SS by RT-SWE were feasible respectively in 87 (99%) and 58 (66%) patients. Both correlated with HVPG (LS: R = 0.611, p < 0.0001 and SS: R = 0.514, p < 0.0001). LS performed well for diagnosing CSPH (optimism corrected AUROC = 0.858). Reliability of measurements was influenced by standard deviation (SD)/median ratio and depth. SD/median