Risk factors for intussusception in infants in Vietnam and Australia: Adenovirus implicated, but not rotavirus
Risk factors for intussusception in infants in Vietnam and Australia: Adenovirus implicated, but not rotavirus
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DOI：
10.1016/j.jpeds.2006.04.010
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发表时间：
2006-10-01
影响因子：
5.1
通讯作者：
Carlin, John B.
中科院分区：
文献类型：
--
作者：
Bines, Julie E.;Liem, Nguyen Thanh;Carlin, John B.
目的本研究旨在探讨发展中国家和发达国家婴儿肠套叠发生的危险因素，其中发展中国家的婴儿肠套叠疑似发病率较高，发达国家的婴儿肠套叠发病率较低。越南（n = 533）和澳大利亚皇家儿童医院（RCH）（n = 51）。由一名独立的盲态放射科医生在一个子集（84% NHP; 67% RCH）中验证诊断。使用标准化问卷进行风险因素评估。结果越南1岁以下婴儿肠套叠的发病率为302/100，000（95%CI：258-352），远高于澳大利亚（71/100，000）。在两个部位均观察到与腺病毒感染的强相关性（NHP阳性病例：34%，OR 8.2; RCH阳性病例：40%，OR 44）。肠套叠和轮状病毒，其他肠道病原体，口服脊髓灰质炎疫苗，喂养的做法，或living conditions.Conclusions之间没有关联的发病率肠套叠婴儿在越南明显高于在澳大利亚。腺病毒感染和肠套叠之间的强关联被确定在这两个网站表明，腺病毒可能发挥作用的病因肠套叠。
Objective This study aimed to investigate risk factors for the development of intussuseeption in infants in a developing country with a suspected high incidence and in a developed country with a low incidence.Study design A prospective case-control study of infants < 2 years of age with idiopathic intussusception confirmed by air enema or surgery was conducted at the National Hospital of Paediatrics (NHP), Vietnam (n = 533) and the Royal Children's Hospital (RCH), Australia (n = 51). Diagnosis was validated in a subset (84% NHP; 67% RCH) by an independent blinded radiologist. Risk factor assessment was performed using a standardized questionnaire. Stool specimens were assayed for bacterial, viral, and parasitic agents.Results The incidence of intussusception in Vietnam was 302/100,000 in infants < 1 year of age (95% CI: 258-352), substantially higher than in Australia (71/100,000). A strong association with adenovirus infection was observed at both sites (cases positive at NHP: 34%, OR 8.2; cases positive at RCH: 40%, OR 44). No association was identified between intussusception and rotavirus, other enteric pathogens, oral polio vaccine, feeding practices, or living conditions.Conclusions The incidence of intussuseeption in infants was markedly higher in Vietnam than in Australia. A strong association between adenovirus infection and intussusception was identified at both sites suggesting that adenovirus may play a role in the etiology of intussuseeption.