Presynaptic targets for acute ethanol sensitivity
Presynaptic targets for acute ethanol sensitivity
复制标题
DOI：
10.1042/bst0380172
复制
发表时间：
2010-02-01
影响因子：
3.9
通讯作者：
Burgoyne, Robert D.
中科院分区：
文献类型：
--
作者：
Barclay, Jeff W.;Graham, Margaret E.;Burgoyne, Robert D.
众所周知，急性接触乙醇会调节神经系统内的信号传递。从生理上讲，这些效应既有突触前的，也有突触后的；然而，更多的研究主要集中在突触后靶点上。最近利用模式生物秀丽Caenarhabditis的研究确定了特定蛋白(Munc18-1和Rab3)和过程(突触小泡招募和融合)在传递乙醇的突触前效应中的作用。在本文中，我们回顾了这些结果，确定了涉及酒精敏感性的蛋白质和蛋白质相互作用，并讨论了它们与哺乳动物酒精滥用研究的联系。
Acute exposure to ethanol is known to modulate signalling within the nervous system. Physiologically these effects are both presynaptic and postsynaptic in origin; however, considerably more research has focused primarily on postsynaptic targets. Recent research using the model organism Caenarhabditis elegans has determined a role for specific proteins (Munc18-1 and Rab3) and processes (synaptic vesicle recruitment and fusion) in transducing the presynaptic effects of ethanol. in the present paper, we review these results, identifying the proteins and protein interactions involved in ethanol sensitivity and discuss their links with mammalian studies of alcohol abuse.