What does the PANSS mean?
What does the PANSS mean?
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DOI：
10.1016/j.schres.2005.04.008
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发表时间：
2005-11-15
影响因子：
4.5
通讯作者：
Engel, RR
中科院分区：
文献类型：
--
作者：
Leucht, S;Kane, JM;Engel, RR
目的：尽管经常使用阳性和阴性症状量表（PANSS）对精神分裂症症状进行评级，但其总评分和用于定义治疗反应的临界值（例如，基线评分降低至少20%或50%）的临床意义尚不清楚。因此，我们比较了PANSS与临床总体不稳定性（CGI）的同时评级。方法：PANSS和CGI评级在基线（n=4091），并在一个汇总的数据库的奥氮平或氨磺必利在精神分裂症急性加重患者的7个关键，多中心抗精神病药物试验采取治疗后的一个，两个，四个和六个星期，使用等百分位数连接进行比较。根据CGI认为“轻度疾病”大致对应于PANSS总分58，“中度疾病”对应于PANSS总分75，“显著疾病”对应于PANSS总分95，重度疾病对应于PANSS总分116。根据CGI评分，“最低限度改善”与第1、2、4和6周PANSS平均百分比降低分别为19%、23%、26%和28%相关。结论：本研究结果为进一步了解PANSS总分在精神分裂症急性加重期药物试验中的临床意义提供了一个较好的框架。理想情况下，此类研究可能使用较基线临界值至少降低50%来定义缓解，而不是使用更低的阈值。然而，在耐药人群中，即使是很小的改善也很重要，因此25%的临界值可能是合适的。(c)2005 Elsevier B.V.保留所有权利。
Objective: Despite the frequent use of the Positive and Negative Syndrome Scale (PANSS) for rating the symptoms of schizophrenia, the clinical meaning of its total score and of the cut-offs that are used to define treatment response (e.g. at least 20% or 50% reduction of the baseline score) are as yet unclear. We therefore compared the PANSS with simultaneous ratings of Clinical Global Impressions (CGI).Method: PANSS and CGI ratings at baseline (n=4091), and after one, two, four and six weeks of treatment taken from a pooled database of seven pivotal, multi-center antipsychotic drug trials on olanzapine or amisulpride in patients with exacerbations of schizophrenia were compared using equipercentile linking.Results: Being considered "mildly ill" according to the CGI approximately corresponded to a PANSS total score of 58, "moderately ill" to a PANSS of 75, "markedly ill" to a PANSS of 95 and severely ill to a PANSS of 116. To be "minimally improved" according to the CGI score was associated with a mean percentage PANSS reduction of 19%, 23%, 26% and 28% at weeks 1, 2, 4 and 6, respectively. The corresponding figures for a CGI rating "much improved" were 40%, 45%, 51% and 53%.Conclusions: The results provide a better framework for understanding the clinical meaning of the PANSS total score in drug trials of schizophrenia patients with acute exacerbations. Such studies may ideally use at least a 50% reduction from baseline cut-off to define response rather than lower thresholds. In treatment resistant populations, however, even a small improvement can be important, so that a 25% cut-off might be appropriate. (c) 2005 Elsevier B.V. All rights reserved.