Par-4 inducible apoptosis in prostate cancer cells
Par-4 inducible apoptosis in prostate cancer cells
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DOI：
10.1002/jcb.20000
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发表时间：
2004-02-15
影响因子：
4
通讯作者：
Rangnekar, VM
中科院分区：
文献类型：
--
作者：
Gurumurthy, S;Rangnekar, VM
Prostate cancer is associated with the inability of prostatic epithelial cells to undergo apoptosis rather than with increased cell proliferation. Prostate apoptosis response-4 (Par-4) is a unique pro-apoptotic molecule that is capable of selectively inducing apoptosis in cancer cells when over-expressed, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. This review discusses the salient functions of Par-4 that can be harnessed to Prostate cancer therapy. (C) 2004 Wiley-Liss, Inc.
