Breast carcinoma in elderly women -: Features of disease presentation, choice of local and systemic treatments compared with younger postmenopausal patients
Breast carcinoma in elderly women -: Features of disease presentation, choice of local and systemic treatments compared with younger postmenopausal patients
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DOI：
10.1002/cncr.20535
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发表时间：
2004-09-15
期刊：
影响因子：
6.2
通讯作者：
Goldhirsch, A
中科院分区：
文献类型：
--
作者：
Gennari, R;Curigliano, G;Goldhirsch, A
背景。衰老仍然是新发乳腺癌的最大危险因素之一。本研究的目的是评估绝经后妇女首次诊断乳腺癌的生物学特征与治疗选择之间的关系：50 年优化老年人治疗。该样本包括1997年4月至2002年2月在欧洲肿瘤研究所（意大利米兰）转诊接受手术的连续2999名绝经后患者。患者根据年龄分组：年轻绝经后（YPM；50-64岁，n = 2052）、老年绝经后（OPM；65-74，n = 801）和老年人绝经后（EPM；大于或等于 75，n = 146）。结果。与 YPM 患者相比，接受手术的 EPM 患者肿瘤更大（pT4：6.7% vs. 2.4%），且淋巴结受累程度更高（淋巴结阳性：62.5% vs. 51.3%）。 EPM患者表现出较高程度的雌激素和孕激素受体表达（P
BACKGROUND. Aging remains one of the single greatest risk factors for the development of new breast carcinoma. The aim of the study was to evaluate the relation between biologic features at first diagnosis of breast carcinoma and treatment choice for postmenopausal women : 50 years to optimize treatment in the elderly.METHODS. The sample included 2999 consecutive postmenopausal patients referred for surgery at the European Institute of Oncology (Milan, Italy) from April 1997 to February 2002. The patients were grouped according to age: young postmenopausal (YPM; 50-64 years, n = 2052), older postmenopausal (OPM; 65-74, n 801), and elderly postmenopausal (EPM; greater than or equal to75, n = 146).RESULTS. EPM patients referred to surgery had larger tumors compared with YPM patients (pT4: 6.7% vs. 2.4%) as well as greater lymph node involvement (lymph node positive: 62.5% vs. 51.3%). EPM patients showed a higher degree of estrogen and progesterone receptor expression (P