THE ALPHA-SPECTRIN GENE IS ON CHROMOSOME-1 IN MOUSE AND MAN
THE ALPHA-SPECTRIN GENE IS ON CHROMOSOME-1 IN MOUSE AND MAN
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DOI：
10.1073/pnas.82.11.3790
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发表时间：
1985-01-01
影响因子：
11.1
通讯作者：
CURTIS, PJ
中科院分区：
文献类型：
--
作者：
HUEBNER, K;PALUMBO, AP;CURTIS, PJ
通过使用α-血影蛋白c[互补]鼠和人来源的DNA克隆以及分离小鼠或人染色体的体细胞杂交体，α-血影蛋白c的基因血影蛋白在两个物种中定位于1号染色体。小鼠的这种分配α-通过DNA杂交将血影蛋白基因与小鼠1号染色体结合加强了先前对α-血影蛋白基因的鉴定。sph基因座，其先前通过连锁分析定位到Pep-3基因座远端的小鼠1号染色体。通过对人中期染色体的原位杂交，人α- spectrin基因定位于1 q22 - 1 q25，非Rh连锁椭圆形红细胞增多症的基因座通过家系连锁研究暂时定位于1 q2带。
By using .alpha.-spectrin c[complementary]DNA clones of murine and human origin and somatic cell hybrids segregating either mouse or human chromosomes, the gene for .alpha.-spectrin was mapped to chromosome 1 in both species. This assignment of the mouse .alpha.-spectrin gene to mouse chromosome 1 by DNA hybridization strengthens the previous identification of the .alpha.-spectrin locus in mouse with the sph locus, which previously was mapped by linkage analysis to mouse chromosome 1, distal to the Pep-3 locus. By in situ hydridization to human metaphase chromosomes, the human .alpha.-spectrin gene was localized to 1q22-1q25; the locus for a non-Rh-linked form of elliptocytosis was provisionally mapped to band 1q2 by family linkage studies.