Ligustrazine improves blood circulation by suppressing Platelet activation in a rat model of allergic asthma
Ligustrazine improves blood circulation by suppressing Platelet activation in a rat model of allergic asthma
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DOI：
10.1016/j.etap.2016.06.016
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发表时间：
2016-07-01
影响因子：
4.3
通讯作者：
Li, Zegeng
中科院分区：
文献类型：
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作者：
Wang, Yajuan;Zhu, Huizhi;Li, Zegeng
川芎(Ligusticum Wallichii)是东亚的一种传统中草药，但其活性成分川芎嗪的作用尚不清楚。我们在一种典型的过敏性哮喘大鼠模型上探讨了它的作用和可能的机制。川芎嗪可抑制哮喘大鼠对乙酰甲胆碱的高反应性，并抑制肺部炎症。川芎嗪具有明显的免疫调节和抗炎作用：抑制哮喘大鼠肺组织中淋巴细胞和嗜酸性粒细胞的动员，减少细胞因子IL-5和IL-13的产生(P
Chuan-xiong (Ligusticum wallichii) is a traditional herbal medicine in Eastern Asia, but the effect of its active component ligustrazine remains unclear. We explored its effect and possible mechanism in a well-characterized rat model of allergic asthma. Ligustrazine suppressed bronchial hyper-responsiveness to methacholine, and suppressed lung inflammation in asthmatic rats. Ligustrazine exhibited potent immuno-modulatory and anti-inflammatory effects: it suppressed lymphocyte and eosinophil mobilization, and reduced cytokine IL-5 and IL-13 production significantly in lung tissues from asthmatic rats (P