Biochemical composition and cariogenicity of dental plaque formed in the presence of sucrose or glucose and fructose
Biochemical composition and cariogenicity of dental plaque formed in the presence of sucrose or glucose and fructose
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DOI：
10.1159/000016629
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发表时间：
2000-11-01
期刊：
影响因子：
4.2
通讯作者：
Tabchoury, CPM
中科院分区：
文献类型：
--
作者：
Cury, JA;Rebelo, MAB;Tabchoury, CPM
评估了在蔗糖或葡萄糖和果糖存在下形成的牙菌斑的组成及其与致龋性的关系。12名成年志愿者参与了这项交叉研究，分三个阶段进行，每个阶段28天。对于每个阶段，为志愿者建造了一个包含四个人牙釉质块的丙烯酸树脂矫治器。将含有20%蔗糖或10%葡萄糖+10%果糖的溶液滴在釉质块上，每天8次，而对照组不使用任何溶液，釉质表面和断面显微硬度结果显示，在蔗糖存在下形成的牙菌斑比在葡萄糖+果糖存在下形成的牙菌斑更容易龋化(p<；0.05)。牙菌斑中碱溶碳水化合物浓度蔗糖组高于对照组和葡萄糖+果糖组(p0.05)。虽然在蔗糖存在下形成的斑块中钙、磷和氟的浓度低于葡萄糖+果糖和对照组，但仅与对照组有显著差异(p0.05)。牙菌斑基质蛋白在没有或存在不同碳水化合物的情况下形成时，其电泳谱表现出明显的模式。虽然结果表明，在蔗糖存在下形成的牙菌斑的高致龋性主要是由于其基质中含有较高浓度的不溶性葡聚糖，但其较低的无机浓度和蛋白质组成可能也有一定的贡献。版权所有(C)2000 S.Karger AG，巴塞尔。
The composition of dental plaque formed in the presence of sucrose or glucose and fructose and its relation to cariogenicity was evaluated. Twelve adult volunteers took part in this crossover study done in three phases of 28 days each. For each phase, an acrylic resin appliance containing four human dental enamel blocks was constructed for the volunteers. Solutions containing 20% sucrose or 10% glucose + 10% fructose were dripped onto the enamel blocks 8 times a day, while in the control group no solution was used, Enamel surface and cross-sectional microhardness results showed that dental plaque formed in the presence of sucrose was more cariogenic than that formed in the presence of glucose + fructose (p< 0.05). The concentration of alkali-soluble carbohydrates in dental plaque was higher in the sucrose group than in the control and glucose + fructose groups (pe 0.05). Although concentrations of Ca, P and F were lower in plaque formed in the presence of sucrose than glucose + fructose and the control, significant differences (pe 0.05) were only observed in relation to control. The electrophoretic profile of the matrix proteins of dental plaque showed distinct patterns when it was formed in the absence or presence of the different carbohydrates. Although the results suggest that the high cariogenicity of dental plaque formed in the presence of sucrose can be mainly explained by the high concentration of insoluble glucans of its matrix, the low inorganic concentration and its protein composition may have some contribution. Copyright (C) 2000 S. Karger AG, Basel.