Investigation into the correlation in SIDS victims between Alzheimer precursor protein A4 in the brainstem and sleep apnea
Investigation into the correlation in SIDS victims between Alzheimer precursor protein A4 in the brainstem and sleep apnea
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DOI：
10.1016/j.earlhumdev.2003.08.005
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发表时间：
2003-12-01
影响因子：
2.5
通讯作者：
Kahn, A
中科院分区：
文献类型：
--
作者：
Sawaguchi, T;Patricia, F;Kahn, A
背景资料：最近，β-淀粉样前体蛋白（APP）的出现已被证明在新生儿脑缺氧缺血性损伤。由于慢性缺氧是婴儿猝死综合征（SIDS）的主要病因之一，因此研究了脑干APP与SIDS睡眠呼吸暂停的相关性。材料与方法：在对27,000名婴儿进行前瞻性研究以描述其睡眠-觉醒行为的过程中，有38名婴儿在6个月以下死亡，其中包括26例SIDS。所有的婴儿都是在死亡前3到12周在儿科睡眠实验室的一个晚上记录的。分析睡眠呼吸暂停的发生频率和持续时间。取脑干组织，用抗阿尔茨海默病前体蛋白A4（APP）进行免疫组化。APP阳性元素的密度进行了半定量测量。APP阳性元素密度与睡眠呼吸暂停相关性分析。结果如下：结论：APP的病理参数与睡眠呼吸暂停的生理参数之间无相关性，这与睡眠呼吸暂停在SIDS病理生理中的相关性不一致。(C)2003爱思唯尔爱尔兰有限公司保留所有权利。
Background: Recently, the appearance of beta-amyloid precursor protein (APP) has been demonstrated in the neonatal brain following hypoxic-ischaemic injury. As chronic hypoxia is one of the favoured theories of causation in the sudden infant death syndrome (SIDS), the correlation between APP in the brainstem and sleep apnea in SIDS was investigated. Materials and methods: Among 27,000 infants studied prospectively to characterize their sleep-wake behavior, 38 infants died under 6 months of age, which included 26 cases of SIDS. All the infants had been recorded during one night in a pediatric sleep laboratory, some 3 to 12 weeks before death. The frequency and duration of sleep apnea were analyzed. The brainstem material was collected and imnumohistochemistry with anti-Alzheimer precursor protein A4 (APP) was carried out. The density of APP-positive elements was measured semi-quantitatively. Correlation analyses were carried out between the density of APP-positive elements and the data on sleep apnea. Results: No correlation was found. Conclusion: No correlation between pathological data of APP and physiological data of sleep apnea was not in agreement with the association of sleep apnea in pathophysiology of SIDS. (C) 2003 Elsevier Ireland Ltd. All rights reserved.