Deep brain stimulation of the pedunculopontine nucleus in Parkinson's disease. Preliminary experience at Oxford.
Deep brain stimulation of the pedunculopontine nucleus in Parkinson's disease. Preliminary experience at Oxford.
复制标题
DOI：
10.1080/02688690802448335
复制
发表时间：
2008-01-01
影响因子：
1.1
通讯作者：
Aziz, T Z
中科院分区：
文献类型：
--
作者：
Pereira, E A;Muthusamy, K A;Aziz, T Z
脚桥核（PPN）脑深部电刺激（DBS）是一种新型神经外科治疗方法，用于治疗帕金森病和相关疾病的步态冻结和姿势不稳定症状。在这里，我们总结了我们的非人灵长类动物和神经影像学研究的相关性，我们的手术靶向的PPN。我们还描述了我们的PPN DBS的临床经验，在低频刺激下实现了最大的运动改善。
Deep brain stimulation (DBS) of the pedunculopontine nucleus (PPN) is a novel neurosurgical therapy developed to address symptoms of gait freezing and postural instability in Parkinson's disease and related disorders. Here, we summarize our non-human primate and neuroimaging research of relevance to our surgical targeting of the PPN. We also describe our clinical experience of PPN DBS with greatest motor improvements achieved by stimulation at low frequencies.