Response to thyrotropin releasing hormone (TRH) in normal man.
Response to thyrotropin releasing hormone (TRH) in normal man.
复制标题
正常人对促甲状腺素释放激素（TRH）的反应。
DOI：
10.1210/jcem-34-2-380
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发表时间：
1972
期刊：
影响因子：
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通讯作者：
R. Utiger
中科院分区：
文献类型：
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作者：
P. Snyder;R. Utiger
对正常人静脉注射合成促甲状腺激素释放激素（TRH），以确定血清促甲状腺激素（TSH）对TRH反应的正常范围和影响这种反应的一些变量。采用TRH后血清TSH的最大增加（最大ΔTSH）作为反应指标。结果表明：（1）当TRH剂量从6.25 μ g增加到400 μg时，ΔTSH最大值呈线性增加;由于800 μg产生的反应不大于400 μg，因此推荐400 μg作为评价TSH分泌的标准试验剂量。2)通过在四种不同情况下向五名受试者中的每一名施用相同剂量（400 μg）的TRH来评价TSH反应的一致性。每名受试者最大ΔTSH的变异系数在4名受试者中为11-22%，在第5名受试者中为40%。3)TSH对TRH的反应性不受性别的显著影响。20-39岁女性的最大ΔTSH为16.8 ± 1.6 μU/ml，身高、性别、年龄组的最大ΔTSH分别为16.8 ± 1.6 μU/ml和1.8 ± 1.6 μU/ml。
Synthetic thyrotropin releasing hormone (TRH) was administered intravenously to normal human subjects to define the normal range of serum thyrotropin (TSH) response to TRH and some of the variables that affect this response. The maximum increase in serum TSH (maximum ΔTSH) following TRH was employed as the index of response. These were the results: 1) The maximum ΔTSH increased linearly when the TRH dose was increased from 6.25 to 400 μg. Since 800 μg produced no greater response than 400 μg, 400 μg is recommended as the standard test dose for evaluating TSH secretion. 2) Consistency of TSH response was evaluated by administration of the same dose (400 μg) of TRH to each of five subjects on four different occasions. The coefficients of variation of the maximum ΔTSH's in each subject ranged from 11–22% in four subjects and was 40% in the fifth. 3) TSH responsiveness to TRH was not significantly affected by sex. maximum ΔTSH in 20–39 year-old females was 16.8 ± 1.6 μU/ml (mean ± sem), and that in height- an...