Stable and dynamic cortical electrophysiology of induction and emergence with propofol anesthesia
Stable and dynamic cortical electrophysiology of induction and emergence with propofol anesthesia
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DOI：
10.1073/pnas.1011949107
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发表时间：
2010-12-07
影响因子：
11.1
通讯作者：
Leuthardt, Eric C.
中科院分区：
文献类型：
--
作者：
Breshears, Jonathan D.;Roland, Jarod L.;Leuthardt, Eric C.
麻醉剂可逆性抑制意识的机制还不完全清楚。先前的功能成像研究表明，丘脑和皮质代谢活动的动态变化，以及代谢定义的功能网络的维持存在，尽管意识丧失。然而，与这些观察结果相关的侵入性电生理学还有待研究。通过直接记录皮层表面的电活动，皮层电图（ECoG）提供了一种强大的方法来整合空间，时间和频谱特征的皮层电生理学不可能与非侵入性的方法。在这项研究中，我们报告了一个独特的全面记录侵入人类皮层生理在诱导和出现从异丙酚麻醉。异丙酚诱导的意识进入和离开的转换（这里定义为反应性）的特征是维持大规模的功能网络，由皮层慢电位的相关波动（
The mechanism(s) by which anesthetics reversibly suppress consciousness are incompletely understood. Previous functional imaging studies demonstrated dynamic changes in thalamic and cortical metabolic activity, as well as the maintained presence of metabolically defined functional networks despite the loss of consciousness. However, the invasive electrophysiology associated with these observations has yet to be studied. By recording electrical activity directly from the cortical surface, electrocorticography (ECoG) provides a powerful method to integrate spatial, temporal, and spectral features of cortical electrophysiology not possible with noninvasive approaches. In this study, we report a unique comprehensive recording of invasive human cortical physiology during both induction and emergence from propofol anesthesia. Propofol-induced transitions in and out of consciousness (defined here as responsiveness) were characterized by maintained large-scale functional networks defined by correlated fluctuations of the slow cortical potential (