Simultaneous magnetoencephalography and SQUID detected nuclear MR in microtesla magnetic fields
Simultaneous magnetoencephalography and SQUID detected nuclear MR in microtesla magnetic fields
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DOI：
10.1002/mrm.20193
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发表时间：
2004-09
影响因子：
3.3
通讯作者：
P. Volegov;A. Matlachov;M. Espy;J. George;R. Kraus
中科院分区：
文献类型：
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作者：
P. Volegov;A. Matlachov;M. Espy;J. George;R. Kraus
设计并制作了一种同时测量脑磁图(MEG)和核磁共振(MRI)信号的系统。将超导量子干涉器件(SQUID)传感器与梯度计拾取线圈相耦合，用来测量核磁共振和脑磁图信号。本文报道了与正中神经诱发的脑磁图反应同时获得的典型Larmor频率为100-1000赫兹的~1H核磁共振波谱。单一的鱿鱼梯度仪被放置在受试者的体感皮层上方，以非侵入性地记录信号。这些测量首次证明了同时进行磁共振成像和脑磁图检查的可行性。微区域的核磁共振提供了窄线宽和高空间分辨率成像的潜力，而SQUID传感器可以通过脑磁图直接测量高时间分辨率的神经元活动。《医学评论》52：467-470,2004。©2004 Wiley-Liss Inc.
A system that simultaneously measures magnetoencephalography (MEG) and nuclear magnetic resonance (NMR) signals from the human brain was designed and fabricated. A superconducting quantum interference device (SQUID) sensor coupled to a gradiometer pickup coil was used to measure the NMR and MEG signals. 1H NMR spectra with typical Larmor frequencies from 100–1000 Hz acquired simultaneously with the evoked MEG response from a stimulus to the median nerve are reported. The single SQUID gradiometer was placed approximately over the somatosensory cortex of a human subject to noninvasively record the signals. These measurements demonstrate, for the first time, the feasibility of simultaneous MRI and MEG. NMR in the microtesla regime provides narrow linewidths and the potential for high spatial resolution imaging, while SQUID sensors enable direct measurement of neuronal activity with high temporal resolution via MEG. Magn Reson Med 52:467–470, 2004. © 2004 Wiley‐Liss, Inc.