Indole derivatization procedures for electron capture negative chemical ionization mass spectrometry: identification of 1-methyl-1,2,3,4-tetrahydro-beta-carboline in rat brain and lung.
Indole derivatization procedures for electron capture negative chemical ionization mass spectrometry: identification of 1-methyl-1,2,3,4-tetrahydro-beta-carboline in rat brain and lung.
复制标题
用于电子捕获负化学电离质谱法的吲哚衍生程序：大鼠脑和肺中 1-甲基-1,2,3,4-四氢-β-咔啉的鉴定。
DOI：
10.1002/bms.1200180407
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Faull,KF
中科院分区：
文献类型：
--
作者：
Bosin,TR;Faull,KF
已经开发了从生物样品中分离具有药理活性的吲哚化合物的程序，并将电子捕获基团，五氟苯基和三氟乙酰基引入到吲哚氮原子上。所得衍生物具有良好的气相色谱性质和较强的电子亲和力，非常适合于检测捕获负化学电离质谱。这些方法被用来鉴定1‐甲基‐1,2,3,4‐四氢‐β‐碳碱作为大鼠脑和肺的成分。
Procedures have been developed for the isolation of pharmacologically active indole compounds from biological samples and for the introduction of electron‐capturing groups, pentafluorobenzyl and trifluoroacetyl, onto the indole nitrogen atom. The resulting derivatives have good gas chromatographic properties and strong electron affinities which make them highly suitable for detection capture negative chemical ionization mass spectrometry. These procedures were used to identify 1‐methyl‐1,2,3,4‐tetrahydro‐β‐carboline as a component of rat brain and lung.