Sex-typed toy play behavior correlates with the degree of prenatal androgen exposure assessed by CYP21 genotype in girls with congenital adrenal hyperplasia
Sex-typed toy play behavior correlates with the degree of prenatal androgen exposure assessed by CYP21 genotype in girls with congenital adrenal hyperplasia
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DOI：
10.1210/jc.2001-011531
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发表时间：
2002-11-01
影响因子：
5.8
通讯作者：
Wedell, A
中科院分区：
文献类型：
--
作者：
Nordenström, A;Servin, A;Wedell, A
先前的研究表明，患有先天性肾上腺皮质增生症（CAH）的女孩在行为上是男性化的，CAH是一种导致胎儿早期肾上腺雄激素过量的综合征。我们研究了在结构化的游戏环境中玩玩具，并将结果与疾病严重程度（通过CYP 21基因分型评估）和诊断时的年龄相关联。CAH的女孩在独自玩耍时比对照组更多地玩男性玩具。此外，我们可以证明疾病严重程度（即胎儿雄激素暴露程度）和行为男性化程度之间的剂量反应关系。父母的存在并没有影响CAH女孩以更男性化的方式玩耍。四CAH女孩与晚诊断也被描述。四个女孩中有三个专门玩一个男性玩具，一个建筑玩具。我们的研究结果支持这样的观点，即产前雄激素暴露对人类大脑有直接的组织影响，以确定性别分型行为的某些方面。（临床内分泌代谢杂志87：5119 - 5124，2002）
Previous studies have shown that girls with congenital adrenal hyperplasia (CAH), a syndrome resulting in overproduction of adrenal androgens from early fetal life, are behaviorally masculinized. We studied play with toys in a structured play situation and correlated the results with disease severity, assessed by CYP21 genotyping, and age at diagnosis. Girls with CAH played more with masculine toys than controls when playing alone. In addition, we could demonstrate a dose-response relationship between disease severity (i.e. degree of fetal androgen exposure) and degree of masculinization of behavior. The presence of a parent did not influence the CAH girls to play in a more masculine fashion. Four CAH girls with late diagnosis are also described. Three of the four girls played exclusively with one of the masculine toys, a constructional toy. Our results support the view that prenatal androgen exposure has a direct organizational effect on the human brain to determine certain aspects of sex-typed behavior. (J Clin Endocrinol Metab 87: 5119 -5124, 2002)