A FAMILY WITH OBSTRUCTIVE CARDIOMYOPATHY (ASYMMETRICAL HYPERTROPHY)
A FAMILY WITH OBSTRUCTIVE CARDIOMYOPATHY (ASYMMETRICAL HYPERTROPHY)
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患有梗阻性心肌病（不对称肥厚）的家庭
DOI：
10.1136/hrt.22.4.449
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发表时间：
1960
影响因子：
--
通讯作者：
J. Renwick
中科院分区：
文献类型：
--
作者：
A. Hollman;J. Goodwin;D. Teare;J. Renwick
在最近的一篇论文中，我们中的一人(Teare，1958)描述了一种迄今鲜为人知的心脏病类型，标题为年轻人心脏不对称性肥大。病变被认为是良性肿瘤或错构瘤，局限于左心室，特别是在间隔区域。其中一名患者是一名21岁的女性，一直在哈默史密斯医院接受治疗，在那里接受常规扁桃体切除术时，偶然发现一名姐妹患有心脏病。不久之后，一个看起来很健康的16岁弟弟在骑自行车上班时摔倒身亡。这些发现使我们对整个家庭进行了研究，本文报道了这一点。我们能够追踪到这个家族的所有成员，总共23人，历经两代人。在19名仍活着的患者中，有14名我们进行了临床、放射学和心电图检查。一名男子(案件3)，47岁，显然身体状况良好，不允许对自己或其四个子女进行检查(案件12至15)。四名死者中有两人有完整的临床细节，三人有尸检结果。我们无法获得关于1923年死亡的男子(病例1)的任何信息，年仅18岁，可能死于脑膜炎(表I)。从家谱可以看出(图1)，我们在这三个兄弟姐妹身上发现了心脏病的证据
In a recent paper, one of us (Teare, 1958) described 8 examples of a hitherto little recognized type of heart disease under the title Asymmetrical hypertrophy of the heart in young adults. The lesion was thought to be a benign tumour or hamartoma and was confined to the left ventricle, especially in the region of the septum. One of these patients, a woman of 21, had been under the care of Hammersmith Hospital, and by chance a sister was found to have heart disease when admitted there for routine tonsillectomy. Shortly afterwards an apparently healthy brother, aged 16, dropped dead when cycling to work. These findings led us to make a study of the entire family which is reported in this paper. We were able to trace all members of the family for two generations, totalling 23 persons. In 14 of the 19 still alive we performed clinical, radiological, and electrocardiographic examinations. One man (Case 3) aged 47, apparently well, would not permit examination of himself or his four children (Cases 12 to 15). Full clinical details were available in two of the four who died, and the autopsy findings in three. We could obtain no information at all on the man (Case 1) who died in 1923, aged 18, possibly of meningitis (Table I). As can be seen from the family tree (Fig. 1), we found evidence of heart disease in the three sibs