Leukocyte removal therapy for ulcerative colitis does not affect postoperative complications
Leukocyte removal therapy for ulcerative colitis does not affect postoperative complications
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DOI：
10.1007/s00535-006-1875-1
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发表时间：
2006-09-01
影响因子：
6.3
通讯作者：
Matsumoto, Takayuki
中科院分区：
文献类型：
--
作者：
Ikeuchi, Hiroki;Yamamura, Takehira;Matsumoto, Takayuki
背景我们调查了接受或未接受术前白细胞清除治疗（LRT）的患者术后并发症的发生率。方法.回顾性分析了387例溃疡性结肠炎（UC）手术治疗的病例记录。109例患者在术前8周内接受了LRT治疗（LRT组），278例患者在术前至少8周后未接受LRT治疗（无LRT组）。我们根据初次手术的类型回顾了术后并发症。结果在接受回肠J型贮袋肛门吻合术（IPAA）而未行回肠造口术的患者中，LRT组有3例（6.5%）发生贮袋相关并发症（PRC），而未行LRT组有11例（7.5%）发生PRC。LRT组的总体术后并发症发生率为28.3%，无LRT组为21.8%。对于接受IPAA和回肠造口术的患者，LRT组的术后并发症总发生率为39.1%，未接受LRT组为31.8%。在接受全结肠切除术的患者中，LRT组有33.3%的患者发生术后并发症，而未接受LRT组有18.2%的患者发生术后并发症。在术后并发症方面，两组之间无统计学显著差异。结论.我们的研究结果表明，术前LRT不会影响UC患者术后并发症的发生率。
Background We investigated the incidence of postoperative complications in patients treated with or without preoperative leukocyte removal therapy (LRT). Methods. The case notes of 387 patients with ulcerative colitis (UC) who underwent surgical intervention were retrospectively reviewed. One hundred nine patients were treated with LRT within 8 weeks before surgery (LRT group), and 278 had not received LRT since at least 8 weeks before surgery (without LRT group). We reviewed the postoperative complications according to type of initial operation. Results. Of the patients who underwent an ileal J-pouch anal anastomosis (IPAA) without an ileostomy, 3 (6.5%) in the LRT group developed pouch-related complications (PRC), while 11 (7.5%) in the without LRT group developed PRC. The overall postoperative complication rates were 28.3% in the LRT group and 21.8% in the without LRT group. For patients who underwent an IPAA with an ileostomy, the overall rates of postoperative complications were 39.1% in the LRT group and 31.8% in the without LRT group. Among those undergoing a total colectomy, 33.3% in the LRT group and 18.2% in the without LRT group had postoperative complications. No statistically significant differences were demonstrated between the two groups with respect to postoperative complications. Conclusions. Our results suggest that preoperative LRT does not influence the rate of postoperative complications in UC patients.