Reproductive factors and risk of hormone receptor positive and negative breast cancer: a cohort study.
Reproductive factors and risk of hormone receptor positive and negative breast cancer: a cohort study.
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DOI：
10.1186/1471-2407-13-584
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发表时间：
2013-12-09
期刊：
影响因子：
3.8
通讯作者：
Kaaks R
中科院分区：
文献类型：
--
作者：
Ritte R;Tikk K;Lukanova A;Tjønneland A;Olsen A;Overvad K;Dossus L;Fournier A;Clavel-Chapelon F;Grote V;Boeing H;Aleksandrova K;Trichopoulou A;Lagiou P;Trichopoulos D;Palli D;Berrino F;Mattiello A;Tumino R;Sacerdote C;Quirós JR;Buckland G;Molina-Montes E;Chirlaque MD;Ardanaz E;Amiano P;Bueno-de-Mesquita HB;van Gils CH;Peeters PH;Wareham N;Khaw KT;Key TJ;Travis RC;Weiderpass E;Dumeaux V;Lund E;Sund M;Andersson A;Romieu I;Rinaldi S;Vineis P;Merritt MA;Riboli E;Kaaks R
生殖因素与激素受体（HR）阴性乳腺肿瘤的相关性仍不确定。在EPIC队列中，使用考克斯比例风险模型来描述生殖因素之间的关系（初潮年龄、初潮与首次怀孕之间的时间、产次、子女数量、首次和最后一次怀孕的年龄、自上次足月分娩以来的时间、母乳喂养、绝经年龄，曾经流产和使用口服避孕药[OC]），具有ER-PR-（n = 998）和ER+PR+（n = 3，567）乳腺肿瘤风险。第一次足月分娩时间较晚与ER+PR+肿瘤风险增加相关，但与ER-PR-肿瘤风险无关（≥35岁vs. ≤19岁HR：1.47 [95% CI 1.15-1.88] p趋势< 0.001，对于ER+PR+肿瘤; ≥35岁vs. ≤19岁HR：0.93 [95% CI 0.53-1.65]，对于ER-PR肿瘤，p趋势= 0.96; P het = 0.03）。月经初潮年龄、月经初潮与首次足月分娩之间的时间段与ER+PR+肿瘤的风险（phet = 0.50）呈相似的方向，尽管程度较弱，统计学上仅具有边缘显著性。其他胎次相关因素，如足月分娩、分娩次数、年龄和自上次分娩以来的时间仅与ER+PR+恶性肿瘤相关，但未观察到乳腺癌亚型之间的统计学异质性。母乳喂养和OC使用通常与乳腺癌亚型风险无关。我们的研究提供了可能的证据表明，初潮年龄，初潮和第一次足月分娩之间的时间可能与HR阴性和HR阳性恶性肿瘤的病因有关，尽管与HR阴性乳腺癌的相关性仅具有边缘显著性。
The association of reproductive factors with hormone receptor (HR)-negative breast tumors remains uncertain. Within the EPIC cohort, Cox proportional hazards models were used to describe the relationships of reproductive factors (menarcheal age, time between menarche and first pregnancy, parity, number of children, age at first and last pregnancies, time since last full-term childbirth, breastfeeding, age at menopause, ever having an abortion and use of oral contraceptives [OC]) with risk of ER-PR- (n = 998) and ER+PR+ (n = 3,567) breast tumors. A later first full-term childbirth was associated with increased risk of ER+PR+ tumors but not with risk of ER-PR- tumors (≥35 vs. ≤19 years HR: 1.47 [95% CI 1.15-1.88] ptrend < 0.001 for ER+PR+ tumors; ≥35 vs. ≤19 years HR: 0.93 [95% CI 0.53-1.65] ptrend = 0.96 for ER-PR- tumors; P het = 0.03). The risk associations of menarcheal age, and time period between menarche and first full-term childbirth with ER-PR-tumors were in the similar direction with risk of ER+PR+ tumors (phet = 0.50), although weaker in magnitude and statistically only borderline significant. Other parity related factors such as ever a full-term birth, number of births, age- and time since last birth were associated only with ER+PR+ malignancies, however no statistical heterogeneity between breast cancer subtypes was observed. Breastfeeding and OC use were generally not associated with breast cancer subtype risk. Our study provides possible evidence that age at menarche, and time between menarche and first full-term childbirth may be associated with the etiology of both HR-negative and HR-positive malignancies, although the associations with HR-negative breast cancer were only borderline significant.
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影响因子：
5.4
作者：
Heuch, I;Albrektsen, G;Kvåle, G
通讯作者：
Kvåle, G
影响因子：
3.3
作者：
James, Rebecca E.;Lukanova, Annekatrin;Kaaks, Rudolf
通讯作者：
Kaaks, Rudolf
影响因子：
7.4
作者：
Allred, DC;Brown, P;Medina, D
通讯作者：
Medina, D
DOI：
10.1186/bcr3186
发表时间：
2012-05-14
期刊：
Breast cancer research : BCR
影响因子：
--
作者：
Ritte R;Lukanova A;Berrino F;Dossus L;Tjønneland A;Olsen A;Overvad TF;Overvad K;Clavel-Chapelon F;Fournier A;Fagherazzi G;Rohrmann S;Teucher B;Boeing H;Aleksandrova K;Trichopoulou A;Lagiou P;Trichopoulos D;Palli D;Sieri S;Panico S;Tumino R;Vineis P;Quirós JR;Buckland G;Sánchez MJ;Amiano P;Chirlaque MD;Ardanaz E;Sund M;Lenner P;Bueno-de-Mesquita B;van Gils CH;Peeters PH;Krum-Hansen S;Gram IT;Lund E;Khaw KT;Wareham N;Allen NE;Key TJ;Romieu I;Rinaldi S;Siddiq A;Cox D;Riboli E;Kaaks R
通讯作者：
Kaaks R
影响因子：
64.8
作者：
Asselin-Labat, Marie-Liesse;Vaillant, Francois;Visvader, Jane E.
通讯作者：
Visvader, Jane E.