High-frequency electric field and radiation characteristics of cellular microtubule network
High-frequency electric field and radiation characteristics of cellular microtubule network
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DOI：
10.1016/j.jtbi.2011.07.007
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发表时间：
2011-10-07
影响因子：
2
通讯作者：
Vrba, J.
中科院分区：
文献类型：
--
作者：
Havelka, D.;Cifra, M.;Vrba, J.
微管是细胞骨架中的重要结构，它组织细胞。由于微管是电极性的，某些微管正常振动模式有效地产生振荡电场。这种振荡场对于细胞内组织和细胞间相互作用可能是重要的。有实验表明，在kHz到GHz的频率范围内，各种细胞都有电动活动，期望微管是这种活动的来源。本文给出了整个细胞微管网络的电场强度和辐射电磁功率的计算结果。微管的亚基（微管蛋白异源二聚体）近似于基本电偶极子。微管的机械振荡由空间函数来表示，空间函数调节亚基的偶极矩。振荡微管周围的场被计算为所有调制的基本电偶极子，其中包括细胞微管网络的贡献的矢量叠加。整个细胞微管网络的电磁辐射和场特性以前没有从理论上分析过。对于未来的实验研究，结果表明，宏观检测系统（天线）是不适合测量细胞的电动力学活动在射频区，因为从单个细胞的辐射率是非常低的（低于10（-20）W）。为了可靠地测量细胞电动力活性，期望能够在细胞附近进行测量的具有高空间分辨率的低噪声纳米级检测方法。(C)2011爱思唯尔有限公司版权所有。
Microtubules are important structures in the cytoskeleton, which organizes the cell. Since microtubules are electrically polar, certain microtubule normal vibration modes efficiently generate oscillating electric field. This oscillating field may be important for the intracellular organization and intercellular interaction. There are experiments which indicate electrodynamic activity of variety of cells in the frequency region from kHz to GHz, expecting the microtubules to be the source of this activity. In this paper, results from the calculation of intensity of electric field and of radiated electromagnetic power from the whole cellular microtubule network are presented. The subunits of microtubule (tubulin heterodimers) are approximated by elementary electric dipoles. Mechanical oscillation of microtubule is represented by the spatial function which modulates the dipole moment of subunits. The field around oscillating microtubules is calculated as a vector superposition of contributions from all modulated elementary electric dipoles which comprise the cellular microtubule network. The electromagnetic radiation and field characteristics of the whole cellular microtubule network have not been theoretically analyzed before. For the perspective experimental studies, the results indicate that macroscopic detection system (antenna) is not suitable for measurement of cellular electrodynamic activity in the radiofrequency region since the radiation rate from single cells is very low (lower than 10(-20) W). Low noise nanoscopic detection methods with high spatial resolution which enable measurement in the cell vicinity are desirable in order to measure cellular electrodynamic activity reliably. (C) 2011 Elsevier Ltd. All rights reserved.