Case-Control Study of Eczema Associated with IL13 Genetic Polymorphisms in Japanese Children
Case-Control Study of Eczema Associated with IL13 Genetic Polymorphisms in Japanese Children
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DOI：
10.1159/000321825
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发表时间：
2011-01-01
影响因子：
2.8
通讯作者：
Hirota, Yoshio
中科院分区：
文献类型：
--
作者：
Miyake, Yoshihiro;Kiyohara, Chikako;Hirota, Yoshio
背景：一些关联研究调查了IL13基因的单核苷酸多态(SNPs)与湿疹的关系，但结果不一致。我们对日本3岁儿童中rs1800925和rs20541基因多态性与湿疹风险的关系进行了病例对照研究。方法：纳入根据国际儿童哮喘和过敏研究(ISAC)标准确定的209例病例。对照组为451名根据Isaac问题没有湿疹的儿童，他们没有被内科医生诊断为哮喘或特应性湿疹。结果：rs1800925 SNP的TT型和rs20541SNP的AA型与湿疹的危险性显著相关：TT型的调整优势比为2.78(95%可信区间1.22~6.30)，AA型的调整优势比为2.38(95%可信区间1.35~4.18)。单倍型分析显示，CG单倍型与湿疹之间存在保护性关联，而TA单倍型与湿疹风险呈正相关。在湿疹的病因中，围产期吸烟暴露与IL13基因的基因型没有交互作用。在对rs1800925 SNP进行额外调整后，rs20541 SNP与湿疹的显著关联基本消失，而与rs1800925 SNP的关联仍然显著。结论：103基因在单个SNPs和单倍型水平上的常见遗传变异与湿疹有关。然而，与rs20541 SNP的显著关联可能归因于rs1800925 SNP。版权所有(C)2010 S.Karger AG，巴塞尔
Background: Several association studies have investigated the relationships between single nucleotide polymorphisms (SNPs) in the IL13 gene and eczema, with inconsistent results. We conducted a case-control study of the relationship between the polymorphisms of rs1800925 and rs20541 and the risk of eczema in Japanese children aged 3 years. Methods: Included were the 209 cases identified based on criteria of the International Study of Asthma and Allergies in Childhood (ISAAC). Controls were 451 children without eczema based on ISAAC questions who had not been diagnosed by a physician as having asthma or atopic eczema. Results: The minor TT genotype of the rs1800925 SNP and the minor AA genotype of the rs20541 SNP were significantly related to an increased risk of eczema: adjusted odds ratio for the TT genotype was 2.78 (95% confidence interval 1.22-6.30) and that for the AA genotype was 2.38(95% confidence interval 1.35-4.18). Haplotype analyses showed a protective association between the CG haplotype and eczema, whereas the TA haplotype was positively related to the risk of eczema. Perinatal smoking exposure did not interact with genotypes of the IL13 gene in the etiology of eczema. The significant association of the rs20541 SNP with eczema essentially disappeared after additional adjustment for the rs1800925 SNP, whereas a relationship with the rs1800925 SNP remained significant. Conclusions: A common genetic variation in the 103 gene at the levels of both single SNPs and haplotypes was associated with eczema. However, the significant association with the rs20541 SNP might be ascribed to the rs1800925 SNP. Copyright (C) 2010 S. Karger AG, Basel