REPRODUCTIVE FUNCTIONS IN YOUNG FATHERS AND GRANDFATHERS
REPRODUCTIVE FUNCTIONS IN YOUNG FATHERS AND GRANDFATHERS
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DOI：
10.1210/jcem-55-4-676
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发表时间：
1982-01-01
影响因子：
5.8
通讯作者：
WICKINGS, EJ
中科院分区：
文献类型：
--
作者：
NIESCHLAG, E;LAMMERS, U;WICKINGS, EJ
对 23 名祖父 [60-88 岁； 67.+-. 7.8（平均值.+-.SD）]，即男性在生命早期就被证明具有生育能力。他们是从非患者群体中招募的，过着积极的生活，其中大多数人都有永久的伴侣。将祖父们与一组 20 位无关的健康父亲（24-37 岁）进行比较 (29.2 .+-. 3.2)。尽管老年组的精子密度较高，但年轻和老年男性的射精量和精子形态没有显着差异。然而，精子活力和精液果糖随着年龄的增长而下降。使用无透明带仓鼠卵进行的异源卵子穿透试验中评估的精子的受精能力并没有随着年龄的增长而显着下降。尽管年轻男性和老年男性的基础血清睾酮和雌二醇水平没有差异，但对 2 天人绒毛膜促性腺激素刺激的反应随着年龄的增长而显着下降。在老年男性中，无论性活动频繁还是不频繁，都会观察到这种下降。老年男性的基础血清 LH [促黄体激素] 和 FSH 水平升高。相对于基础值，LH 对促性腺激素刺激的反应显着降低，而 FSH 反应不随年龄变化。精子数量和精子的受精能力不会受到老年的负面影响，至少对于持续性活动的男性来说是这样。然而，垂体和睾丸在老年时表现出内分泌储备能力下降的迹象。
Testicular functions were investigated in 23 grandfathers [60-88 yr old; 67 .+-. 7.8 (mean .+-. SD)], i.e., men with fertility proven earlier in life. They were recruited from a non-patient population and led an active life, most of them with a permanent partner. The grandfathers were compared with a group of 20 unrelated healthy fathers, 24-37 yr old (29.2 .+-. 3.2). Whereas sperm density was higher in the older group, there were no significant differences in ejaculate volume and sperm morphology between the younger and older men. Sperm motility and seminal fructose, however, decreased with age. The fertilizing capacity of sperm as assessed in the heterologous ovum penetration test using zona pellucida-free hamster eggs did not decrease significantly with age. Whereas the basal serum testosterone and estradiol levels were not different between the younger and older men, the response to 2 days of human chorionic gonadotropin stimulation decreased significantly with age. This decrease was observed in older men whether they had frequent or infrequent sexual activity. Basal serum LH [lutropin] and FSH levels were elevated in the older men. The LH response to gonadoliberin stimulation relative to basal values was significantly reduced, while FSH responses did not change with age. Sperm counts and fertilizing capacity of sperm are not negatively influenced by old age, at least not in men with sustained sexual activity. However, the pituitary and the testis show signs of decreased endocrine reserve capacity in old age.