Working Memory Performance Correlates with Prefrontal-Hippocampal Theta Interactions but not with Prefrontal Neuron Firing Rates.
Working Memory Performance Correlates with Prefrontal-Hippocampal Theta Interactions but not with Prefrontal Neuron Firing Rates.
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DOI：
10.3389/neuro.07.002.2010
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发表时间：
2010
影响因子：
3.5
通讯作者：
Hasselmo ME
中科院分区：
文献类型：
--
作者：
Hyman JM;Zilli EA;Paley AM;Hasselmo ME
内侧前额叶皮层（mPFC）或海马（HPC）的损伤会损害记忆任务的表现;尽管这两个区域如何有助于成功的表现还不清楚。mPFC单位的活动是暂时的影响，与几乎一半的mPFC人口夹带到θ角的行为动物，θ角的相互作用的机制，使这两个领域之间的合作。mPFC神经元在工作记忆任务中对感觉刺激和反应做出反应，尽管这些相关的放电率变化的功能仍然不清楚，因为在mPFC依赖和独立任务中报告了类似的反应。使用DNMS任务，我们比较了错误试验与正确试验，发现几乎所有的mPFC细胞在错误和正确试验期间都以相似的速率发射（92%），但是mPFC神经元的θ夹带在错误表现期间下降，因为只有17%的细胞是θ夹带的（在正确试验期间，46%的群体是θ夹带的）。在整个人群中，错误和正确的试验在发射率上没有差异，但θ-夹带受损。θ-夹带和发射率变化的周期似乎是独立变量，并且只有θ-夹带与成功的性能相关，表明mPFC-HPC θ-范围相互作用是成功DNMS性能的关键。
Performance of memory tasks is impaired by lesions to either the medial prefrontal cortex (mPFC) or the hippocampus (HPC); although how these two areas contribute to successful performance is not well understood. mPFC unit activity is temporally affected by hippocampal-theta oscillations, with almost half the mPFC population entrained to theta in behaving animals, pointing to theta interactions as the mechanism enabling collaborations between these two areas. mPFC neurons respond to sensory stimuli and responses in working memory tasks, though the function of these correlated firing rate changes remains unclear because similar responses are reported during mPFC dependent and independent tasks. Using a DNMS task we compared error trials vs. correct trials and found almost all mPFC cells fired at similar rates during both error and correct trials (92%), however theta-entrainment of mPFC neurons declined during error performance as only 17% of cells were theta-entrained (during correct trials 46% of the population was theta-entrained). Across the population, error and correct trials did not differ in firing rate, but theta-entrainment was impaired. Periods of theta-entrainment and firing rate changes appeared to be independent variables, and only theta-entrainment was correlated with successful performance, indicating mPFC-HPC theta-range interactions are the key to successful DNMS performance.