Fragile hearts: new insights into translational control in cardiac muscle.
Fragile hearts: new insights into translational control in cardiac muscle.
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DOI：
10.1016/j.tcm.2013.03.003
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发表时间：
2013-11
影响因子：
9.3
通讯作者：
Gregorio CC
中科院分区：
文献类型：
--
作者：
Zarnescu DC;Gregorio CC
目前的研究主要集中在横纹肌中的RNA结合蛋白，它提供了一种情况，即肌肉功能和发育是由转录后RNA调节的相互作用控制的，包括转录本定位、剪接、稳定性和翻译控制。最近出现的新数据将 RNA 结合蛋白 FXR1 与关键细胞骨架成分（如心肌中的踝蛋白和桥粒斑蛋白）的翻译联系起来。这些发现，加上最近大量的报告表明，RNA 结合蛋白及其 RNA 靶点在肌肉发育和分化的基本方面以及心脏病和肌肉营养不良症中发挥着重要作用，表明基于 RNA 的调节机制在肌肉生物学中发挥着关键作用。在这里，我们重点关注 FXR1（RNA 结合蛋白脆性 X 家族的横纹肌特异性成员），并讨论其新报道的细胞骨架靶标以及对心脏病的潜在影响。
Current investigations focused on RNA-binding proteins in striated muscle, which provide a scenario whereby muscle function and development are governed by the interplay of post-transcriptional RNA regulation, including transcript localization, splicing, stability, and translational control. New data have recently emerged, linking the RNA-binding protein FXR1 to the translation of key cytoskeletal components such as talin and desmoplakin in heart muscle. These findings, together with a plethora of recent reports implicating RNA-binding proteins and their RNA targets in both basic aspects of muscle development and differentiation as well as heart disease and muscular dystrophies, point to a critical role of RNA-based regulatory mechanisms in muscle biology. Here we focus on FXR1, the striated muscle-specific member of the Fragile X family of RNA-binding proteins and discuss its newly reported cytoskeletal targets as well as potential implications for heart disease.