Impact of race and ethnicity on features and outcome of ductal carcinoma in situ of the breast
Impact of race and ethnicity on features and outcome of ductal carcinoma in situ of the breast
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DOI：
10.1002/cncr.27707
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发表时间：
2013-01-01
期刊：
影响因子：
6.2
通讯作者：
Brewster, Abenaa M.
中科院分区：
文献类型：
--
作者：
Bailes, Adele A.;Kuerer, Henry M.;Brewster, Abenaa M.
背景：在已发表的文献中，种族和民族对诊断为浸润前乳腺癌原位癌（DCIS）的女性的生物学特征和结局变量的影响尚未得到广泛讨论。方法：分析1996年至2009年接受单纯DCIS治疗的女性患者的人口统计学、临床、病理特征和结果变量，以及患者最初自我报告的种族/民族。结果：1902例患者中，白人1411例（74.2%），非裔美国人214例（11.3%），西班牙裔175例（9.1%），亚裔/太平洋岛民102例（5.4%）。大多数患者年龄在41 ~ 70岁之间（83%）。西班牙裔和亚洲/太平洋岛民后裔的患者明显比白人和非洲裔美国患者年轻（P < 0.001）。DCIS的大小和分级、坏死的存在以及保乳手术的频率在两组之间没有显著差异。非裔美国患者年龄为60 ~ 70岁，西班牙裔患者年龄为60 ~ 70岁
BACKGROUND: The impact of race and ethnicity on the biologic features and outcome variables of women who are diagnosed with preinvasive breast cancerductal carcinoma in situ (DCIS)has not been addressed widely in the published literature. METHODS: Patient demographic, clinical, and pathologic features and outcome variables were analyzed with respect to the patient's initial self-reported race/ethnicity among women who received treatment for a diagnosis of pure DCIS from 1996 to 2009. RESULTS: Of 1902 patients, 1411 were white (74.2%), 214 were African American (11.3%), 175 were Hispanic (9.1%), and 102 were Asian/Pacific Islander (5.4%). The majority of patients were between ages 41 and 70 years (83%). Patients of Hispanic and Asian/Pacific Islander descent were significantly younger than white and African American patients (P < .001). DCIS size and grade, the presence of necrosis, and the frequency of breast-conserving surgery did not differ significantly between groups. African American patients aged >70 years and Hispanic patients aged