β2-glycoprotein 1-dependent anticardiolipin antibodies and risk of ischemic stroke and myocardial infarction -: The Honolulu Heart Program
β2-glycoprotein 1-dependent anticardiolipin antibodies and risk of ischemic stroke and myocardial infarction -: The Honolulu Heart Program
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DOI：
10.1161/01.str.32.8.1701
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发表时间：
2001-08-01
期刊：
影响因子：
8.3
通讯作者：
Kittner, SJ
中科院分区：
文献类型：
--
作者：
Brey, RL;Abbott, RD;Kittner, SJ
研究背景：据推测，对β(2)-糖蛋白1 （β 2GP1）依赖的抗心磷脂抗体（aCL）的免疫反应性与缺血性卒中和心肌梗死（MI）的风险增加有关，而非β 2GP1独立的aCL。方法：我们进行了一项巢式病例对照研究，通过使用从檀香山心脏项目登记的受试者中获得的储存冷冻血清，并随访20年，检查aCL作为缺血性卒中和心肌梗死的危险因素。我们测量了259名发生缺血性中风的男性、374名发生mi的男性和1360名没有这两种情况的对照组的β 2GP1依赖性和β 2GP1非依赖性aCL和抗β 2GP1免疫反应性。结果：仅β 2gp1依赖性的IgG类aCL与缺血性卒中和心肌梗死发生率显著相关。在20年随访的最后5年，这种关联减弱。对于中风，经危险因素调整后，15岁时β 2gp1依赖性aCL阳性与IgG类阴性的男性相对危险率为2.2 (95% CI 1.5 - 3.4)， 20岁时为1.5 （95% CI 1.0 - 2.3）。对于心肌梗死，15年调整后的相对危险度为1.8 (95% CI 1.2 - 2.6)， 20年调整后的相对危险度为1.5 （95% CI 1.1 - 2.1）。结论：这些数据表明，aCL IgG，尤其是β 2GP1依赖性的IgG，是男性未来卒中和心肌梗死的重要预测因子。
Background-It has been hypothesized that immunoreactivity to beta (2)-glycoprotein 1 (beta 2GP1)-dependent anticardiolipin antibody (aCL), but not beta 2GP1 -independent aCL, is associated with increased risk of ischemic stroke and myocardial infarction (MI).Methods-We performed a nested case-control study examining aCL as a risk factor for ischernic stroke and MI by using stored frozen sera obtained from subjects enrolled in the Honolulu Heart Program and followed for up for 20 years. We measured beta 2GP1-dependent and beta 2GP1-independent aCL and anti-beta 2GP1 immunoreactivity in 259 men who developed an ischemic stroke, in 374 men who developed an MI. and in a control group of 1360 men who remained free of both conditions.Results-Only beta 2GP1-dependent aCL of the IgG class was significantly associated with both incident ischemic stroke and MI. This association was attenuated in the last 5 years of the 20-year follow-up. For stroke, the risk factor-adjusted relative odds for men with a positive versus a negative beta 2GP1-dependent aCL of the IgG class were 2.2 (95% CI 1.5 to 3.4) at 15 years and 1.5 (95% CI 1.0 to 2.3) at 20 years. For MI, the adjusted relative odds were 1.8 (95% CI 1.2 to 2.6) at 15 years and 1.5 (95% CI 1.1 to 2.1) at 20 years.Conclusions-These data suggest that aCL IgG, particularly the beta 2GP1 -dependent variety, is an important predictor of future stroke and MI in men.