Comparison of 8, 10, 12, 16, 20 cores prostate biopsies in the determination of prostate cancer and the importance of prostate volume.
Comparison of 8, 10, 12, 16, 20 cores prostate biopsies in the determination of prostate cancer and the importance of prostate volume.
复制标题
DOI：
10.5489/cuaj.510
复制
发表时间：
2014-01-01
期刊：
影响因子：
--
通讯作者：
Baytok, Ozkan
中科院分区：
文献类型：
--
作者：
Ceylan, Cavit;Doluoglu, Omer Gokhan;Baytok, Ozkan
简介：在本研究中，我们评估了核心数量增加与癌症检出率之间的关系。方法：本研究纳入了 1120 名前列腺特异性抗原水平≤20 ng/mL 和/或直肠指检结果可疑的患者。所有患者均进行了首次前列腺活检，并在研究期间对不同组进行了 8、10、12、16 和 20 个核心活检并进行检查。通过多元逻辑回归分析得出影响癌症患者与非癌症患者之间癌症检出率的因素。 p < 0.05 被认为具有统计学意义。 结果：1120 名患者中，221 名 (19.7%) 患有前列腺癌。同样，在 1120 名患者中，有 229 名患者 (20.4%) 进行了 8 份核心活检； 473 例 (42.2%) 中进行了 10 次核心活检； 100 份中的 12 份核心活检（8.9%）； 140 份（12.5%）中的 16 份核心活检；以及来自 178 名 (15.9%) 患者的 20 份核心活检。核心数量的增加使癌症检出率提高了1.06倍（p = 0.008）。结论：只要前列腺体积增加，增加核心数量就会提高癌症检出率。因此，漏诊癌症的几率将会降低，不必要的重复活检的几率也会降低。
INTRODUCTION: In this study, we evaluate the relationship between increasing core numbers and cancer detection rate.METHODS: We included 1120 patients with prostate-specific antigen levels ≤20 ng/mL and/or suspicious digital rectal examination findings in this study. All patients had a first-time prostate biopsy and 8, 10, 12, 16, and 20 core biopsies were taken and examined in different groups during the study. Multiple logistic regression analysis was made to reach the factor affecting the cancer detection rate between the patients with and without cancer. A p < 0.05 was considered statistically significant.RESULTS: Out of 1120 patients, 221 (19.7%) had prostate cancer. Again of the total 1120 patients, 8 core biopsies were taken from 229 (20.4%); 10 core biopsies from 473 (42.2%); 12 core biopsies from 100 (8.9%); 16 core biopsies from 140 (12.5%); and 20 core biopsies from 178 (15.9%) patients. The increase in the core number increased the cancer detection rate by 1.06 times (p = 0.008).CONCLUSIONS: As long as prostate volume increases, increasing the core number elevates the cancer detection rate. Thus, the rate of missed cancer will be reduced and the rates of unnecessary repetitive biopsy decreases.