An Evaluation of Hyperkalemia and Serum Creatinine Elevation Associated With Different Dosage Levels of Outpatient Trimethoprim-Sulfamethoxazole With and Without Concomitant Medications
An Evaluation of Hyperkalemia and Serum Creatinine Elevation Associated With Different Dosage Levels of Outpatient Trimethoprim-Sulfamethoxazole With and Without Concomitant Medications
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DOI：
10.1177/1060028013509973
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发表时间：
2013-12-01
影响因子：
2.9
通讯作者：
Nguyen, Ann T.
中科院分区：
文献类型：
--
作者：
Gentry, Chris A.;Nguyen, Ann T.
背景资料：与大剂量甲氧苄啶-磺胺甲恶唑（TMP-SMX）治疗门诊感染相关的不良事件，特别是那些可能由社区获得性耐甲氧西林金黄色葡萄球菌引起的不良事件，尚未得到充分表征。目的：描述与大剂量川芎嗪相关的高钾血症和急性肾损伤。研究方法：对接受高剂量和低剂量TMP-SMX的门诊患者进行了一项电子病历数据库回顾性研究，比较了高钾血症和急性肾损伤的发生率。结果：6162例患者中，高钾血症发生率（3.06%vs1.05%，P <0.05）高于高钾血症（OR = 3.44，95%CI = 1.86-7.0，P <0.05），高钾血症发生率（3.06%vs1.05%，P <0.05）高于高钾血症（OR = 3.44，95%CI = 1.86-7.0，P <0.05），高钾血症发生率（3.06%vs1.05%，P <0.05）高于高钾血症发生率（3.06%vs1.05%，P <0.05）。
Background: Adverse events associated with high-dose trimethoprim-sulfamethoxazole (TMP-SMX) for outpatient infections, particularly those likely caused by community-acquired methicillin-resistant Staphylococcus aureus, have not been adequately characterized. Objective: Describe hyperkalemia and acute renal injury associated with high-dose TMP-SMX. Methods: An electronic medical record database retrospective study was conducted of outpatients receiving high-dose on low-dose TMP-SMX, comparing the incidences of hyperkalemia and acute renal injury. Results: Of 6162 patients, more developed hyperkalemia (3.06% vs 1.05%, P58 years (odds ratio [OR] = 3.44; 95% CI = 1.86-7.0; p