Establishment and characterization of a multi-purpose large animal exposure chamber for investigating health effects
Establishment and characterization of a multi-purpose large animal exposure chamber for investigating health effects
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DOI：
10.1063/1.5042097
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发表时间：
2019-03-01
影响因子：
1.6
通讯作者：
Cocker, David R.
中科院分区：
文献类型：
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作者：
Peng, Xinze;Maltz, Mia R.;Cocker, David R.
空气污染对环境和人类健康构成重大威胁。大多数针对空气污染物（包括颗粒物（PM）和气相污染物）进行的体内健康研究都是通过传统的医学鼻内治疗或使用限制动物活动的小室。在这项研究中，我们设计并测试了一个大型、全身、多动物暴露室，其具有均匀的分散性和暴露稳定性，用于动物研究。该室同时控制颗粒尺寸分布和 PM 质量浓度。使用两种不同的方法通过可溶性材料（链格孢提取物）、液体颗粒悬浮液（纳米二氧化硅溶液）或干粉（二氧化硅粉末）产生气溶胶悬浮液。我们证明，该室系统提供了良好控制和表征的整个动物暴露，其中剂量是通过吸入颗粒物质来进行的。由 AlP Publishing 许可出版。
Air pollution poses a significant threat to the environment and human health. Most in vivo health studies conducted regarding air pollutants, including particulate matter (PM) and gas phase pollutants, have been either through traditional medical intranasal treatment or using a tiny chamber, which limit animal activities. In this study, we designed and tested a large, whole-body, multiple animal exposure chamber with uniform dispersion and exposure stability for animal studies. The chamber simultaneously controls particle size distribution and PM mass concentration. Two different methods were used to generate aerosol suspension through either soluble material (Alternaria extract), liquid particle suspension (nanosilica solution), or dry powder (silica powder). We demonstrate that the chamber system provides well controlled and characterized whole animal exposures, where dosage is by inhalation of particulate matter. Published under license by AlP Publishing.