NEUROLOGICAL AND EEG FINDINGS IN THE MONKEY AFTER TOTAL BODY X-IRRADIATION
NEUROLOGICAL AND EEG FINDINGS IN THE MONKEY AFTER TOTAL BODY X-IRRADIATION
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DOI：
10.1016/0013-4694(53)90013-3
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发表时间：
1953-01-01
期刊：
影响因子：
--
通讯作者：
TROWBRIDGE, WV
中科院分区：
文献类型：
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作者：
ELDRED, E;TROWBRIDGE, WV
随着放射病症状的出现，出现了包括厌食、精神萎靡和运动功能减退在内的行为改变，并且在病情严重的动物中，在死亡前发展为虚脱和昏迷。在这些病情严重的猴子中，虹膜和腱反射受到抑制，其中1例最终出现颈部和上肢抽搐样抽搐。在康复期和幸存病例中，没有表现出行为或神经异常。正常猴子脑电图的初步研究。揭示了与警觉或兴奋相关的低电压快速放电，阿尔法节律为 7-9.5/秒。在放松的清醒状态下，大1-2次/秒。困倦或睡眠时出现驼峰或波浪。正常动物中戊巴比妥麻醉的诱导与规则的高振幅 1/秒之前的一段低速放电有关。波浪出现了。整体脑电图。照射后的图像与正常图像相比没有明显变化。然而，从辐射当天起，一些动物的α节律出现轻微减慢和更大的不规则性。在临终阶段，脑电图。被极大地改变并由高压慢波组成，在死亡前被几乎等电追踪所取代。这些最终改变似乎是体内平衡总体崩溃的继发因素。目前的研究结果被认为与其他研究结果一致，表明神经系统对辐射具有高度抵抗力。
With the onset of symptoms of radiation sickness, behavioral alterations consisting of anorexia, listlessness and hypokinesia appeared and, in severely ill animals, progressed to prostration and coma before death. Depression of iridal and tendon reflexes was encountered in such severely ill monkeys and, in 1 case, tic-like jerks of the neck and upper extremities were displayed terminally. In convalescent and surviving cases, no behavioral or neurological abnormalities were exhibited. Preliminary study of the normal monkey''s eeg. revealed low voltage fast discharge associated with alertness or excitement, an alpha rhythm of 7-9.5/sec. in relaxed wakefulness, and large 1-2/sec. humps or waves with drowsiness or sleep. Induction of Nembutal anesthesia in the normal animal was associated with a period of low fast discharge before regular, high amplitude 1/sec. waves appeared. The overall eeg. picture after irradiation was not changed significantly from normal. However, a slight slowing and greater irregularity of the alpha rhythm was present in several animals from the day of irradiation. In pre-terminal stages, the eeg. was greatly altered and consisted of high voltage slow waves which gave way to an almost iso-electric tracing before death. These terminal alterations appeared secondary to the general breakdown of homeostasis. The present findings are considered to be in accord with those of others which point to a high degree of resistance of the nervous system to irradiation.