Improvement of reduced electroretinographic responses in thymoma-associated retinopathy: a case report and literature review.
Improvement of reduced electroretinographic responses in thymoma-associated retinopathy: a case report and literature review.
复制标题
胸腺瘤相关视网膜病视网膜电图反应减少的改善：病例报告和文献综述。
DOI：
10.1007/s10633-020-09764-1
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Nakano T
中科院分区：
文献类型：
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作者：
Mizobuchi K;Hayashi T;Katagiri S;Kim E;Ishiba Y;Watanabe S;Furukawa T;Nakano T
目的报道1例胸腺瘤相关性视网膜病变患者，其视力预后良好。方法病例报道和文献复习。病例报道1例女性患者，42岁，因双眼突然出现视野缺陷而就诊。十进制矫正视力(VA)右眼为1.5，左眼为1.2。眼底自发荧光显示双眼视网膜从后极部到中周视网膜呈高自发荧光。在暗视和明视条件下，全场视网膜电图(ERG)波幅分别降低到对照组的20%-50%和30%-50%。全身检查发现胸腺瘤的存在，患者接受了胸腺切除和免疫抑制治疗。用患者血清进行的免疫组织化学分析显示，猴子视网膜的光感受器内段和外丛状层进行了免疫标记。两年后，RE和LE的视力分别维持在1.5和1.2。在暗视条件下，ERG波幅提高到对照组的30-60%。结论据我们所知，7例胸腺瘤相关性视网膜病变患者的视杆介导的ERG反应未见改善。我们患者良好的视力预后可能与恰当的干预有关。
PurposeTo report a patient with thymoma-associated retinopathy presenting as having a good visual prognosis.MethodsCase report and literature review.Case reportA 42-year-old female patient was referred to our hospital for complaints of sudden visual-field defects bilaterally. Decimal corrected visual acuity (VA) was 1.5 and 1.2 in the right (RE) and left eyes (LE), respectively. Fundus autofluorescence revealed hyper-autofluorescence from the posterior pole to mid-peripheral retina in both eyes. Full-field electroretinography (ERG) amplitudes were reduced to 20–50% and 30–50% of our controls for the scotopic and photopic conditions, respectively. A systemic examination revealed the presence of thymoma, and the patient underwent thymectomy and immunosuppression therapies. Immunohistochemical analysis using the patient’s serum showed immunolabeling on the photoreceptor inner segment and outer plexiform layer in the monkey retina. Two years later, VA remained at 1.5 and 1.2 in RE and LE. ERG amplitudes improved to 30–60% of the controls for the scotopic conditions. However, photopic ERG showed no remarkable change.ConclusionsTo our knowledge, improvement of reduced rod-mediated ERG responses has not been described in seven previously reported patients with thymoma-associated retinopathy. The good visual prognosis of our patient may be associated with well-timed intervention.