Risk of endometrial cancer in relation to medical conditions and medication use.
Risk of endometrial cancer in relation to medical conditions and medication use.
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DOI：
10.1158/1055-9965.epi-08-0936
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发表时间：
2009-05
期刊：
影响因子：
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通讯作者：
Olson SH
中科院分区：
文献类型：
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作者：
Fortuny J;Sima C;Bayuga S;Wilcox H;Pulick K;Faulkner S;Zauber AG;Olson SH
我们研究了与肥胖相关的医疗条件和用于这些条件的药物与子宫内膜癌的关系。我们还调查了其他医疗条件和药物与风险的关系。这项基于美国人群的病例对照研究包括469例子宫内膜癌病例和467例对照。通过个人访谈收集关于子宫内膜癌的假定危险因素的信息。我们询问了女性的病史和使用6个月或更长时间的药物，以及每种药物的使用年限。风险与肥胖增加密切相关（趋势p <0.001）。在与肥胖相关的疾病中，在校正年龄、体重指数（BMI）和其他危险因素和疾病后，子宫肌瘤与癌症风险增加独立相关（校正OR= 1.8，95%CI= 1.2-2.5）。尽管在校正年龄和BMI后，高血压与子宫内膜癌无显著相关性，但噻嗪类利尿剂的使用与风险增加独立相关（OR= 1.8，95%CI= 1.1-3.0）。贫血与风险降低相关（OR= 0.6，95%CI= 0.5-0.9）。使用非甾体类抗炎药与风险降低有关（OR= 0.7，95%CI= 0.5-0.97）。据我们所知，关于噻嗪类利尿剂的观察结果是新的，需要在其他研究和人群中证实。
We studied the relation of medical conditions related to obesity and medications used for these conditions with endometrial cancer. We also investigated the association of other medical conditions and medications with risk. This US population-based case-control study included 469 endometrial cancer cases and 467 controls. Information on putative risk factors for endometrial cancer was collected through personal interviews. We asked women about their medical history and medications used for six months or longer and the number of years each medication was taken. Risk was strongly associated with increasing obesity (p for trend <0.001). Among conditions related to obesity, and after adjustment for age, body mass index (BMI), and other risk factors and conditions, uterine fibroids were independently related to an increased cancer risk (adjusted OR= 1.8, 95%CI= 1.2–2.5). Although hypertension was not significantly related to endometrial cancer after adjustment for age and BMI, use of thiazide diuretics was independently associated with an increased risk (OR= 1.8, 95%CI= 1.1–3.0). Anemia was associated with decreased risk (OR= 0.6, 95%CI= 0.5–0.9). Use of non-steroidal anti-inflammatory drugs was related to a decreased risk (OR= 0.7, 95%CI= 0.5–0.97). To our knowledge, the observation about thiazide diuretics is novel and requires confirmation in other studies and populations.