MDMA enhances "mind reading" of positive emotions and impairs "mind reading" of negative emotions
MDMA enhances "mind reading" of positive emotions and impairs "mind reading" of negative emotions
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DOI：
10.1007/s00213-012-2645-9
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发表时间：
2012-07-01
影响因子：
3.4
通讯作者：
Liechti, Matthias E.
中科院分区：
文献类型：
--
作者：
Hysek, Cedric M.;Domes, Gregor;Liechti, Matthias E.
3,4 - 亚甲基二氧基甲基苯丙胺（MDMA，摇头丸）会增加社交性。MDMA的亲社会效应可能源于“社交激素”催产素的释放以及社会情感刺激处理过程中的相关变化。我们研究了MDMA（125毫克）对通过眼睛区域的社交线索推断他人心理状态能力的影响，采用的是“读心眼神测试”。该研究包括48名健康志愿者（24名男性，24名女性），采用双盲、安慰剂对照、被试内设计。使用选择反应时测试来排除精神运动功能的损伤。我们还测量了循环中的催产素和皮质醇水平以及主观药物效应。
MDMA对读心能力的影响因刺激的情感效价而异。MDMA提高了对积极刺激（例如友好的）心理状态解码的准确性，损害了对消极刺激（例如敌对的）的读心能力，对中性刺激（例如沉思的）的读心能力没有影响。MDMA没有影响精神运动表现，提高了循环中的催产素和皮质醇水平，并产生了主观的亲社会效应，包括感觉更开放、健谈以及与他人更亲近。
正确解读社会情感信息的能力向与积极情感效价相关的刺激转变，连同MDMA引发的亲社会情感，可能会在MDMA被用于娱乐时增强社交趋近行为和社交性，并促进MDMA辅助心理治疗环境中的治疗关系。
3,4-Methylenedioxymethamphetamine (MDMA, ecstasy) increases sociability. The prosocial effects of MDMA may result from the release of the "social hormone" oxytocin and associated alterations in the processing of socioemotional stimuli.We investigated the effects of MDMA (125 mg) on the ability to infer the mental states of others from social cues of the eye region in the Reading the Mind in the Eyes Test. The study included 48 healthy volunteers (24 men, 24 women) and used a double-blind, placebo-controlled, within-subjects design. A choice reaction time test was used to exclude impairments in psychomotor function. We also measured circulating oxytocin and cortisol levels and subjective drug effects.MDMA differentially affected mind reading depending on the emotional valence of the stimuli. MDMA enhanced the accuracy of mental state decoding for positive stimuli (e.g., friendly), impaired mind reading for negative stimuli (e.g., hostile), and had no effect on mind reading for neutral stimuli (e.g., reflective). MDMA did not affect psychomotor performance, increased circulating oxytocin and cortisol levels, and produced subjective prosocial effects, including feelings of being more open, talkative, and closer to others.The shift in the ability to correctly read socioemotional information toward stimuli associated with positive emotional valence, together with the prosocial feelings elicited by MDMA, may enhance social approach behavior and sociability when MDMA is used recreationally and facilitate therapeutic relationships in MDMA-assisted psychotherapeutic settings.