A high field gradient magnet for magnetic drug targeting
A high field gradient magnet for magnetic drug targeting
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DOI：
10.1109/tasc.2005.864457
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发表时间：
2006-06-01
影响因子：
1.8
通讯作者：
Weber, Horst
中科院分区：
文献类型：
--
作者：
Alexiou, Christoph;Diehl, Dirk;Weber, Horst
设计、制造和测试了一种磁性药物靶向磁体。该磁体对磁流体施加磁力，与用于医疗和生物应用的治疗剂相结合，例如用于癌症的区域治疗。癌症治疗的应用需要在肿瘤周围和内部的应用体积中具有高的磁场梯度。此外，磁体应具有低质量和小尺寸，并具有适当的几何形状，便于在患者附近操作和定位，并且表面温度低于40摄氏度。磁场的梯度决定了小的单磁区铁磁性颗粒的磁力，范围从极尖的100T/m到最小10微米，应用体积为20 mm(3)，并向内指向极尖的中心。
A magnet for Magnetic Drug Targeting was designed, built and tested. The magnet applies a magnetic force on ferrofluids coupled with therapeutic agents for medical and biological applications, e.g. for regional treatment of cancer. The application for cancer treatment requires a high magnetic field gradient in the application volume around and inside the tumor. Furthermore the magnet should have low mass and size combined with an appropriate geometry for easy handling and positioning near the patient, as well as a surface temperature below 40 degrees C. The gradient of the magnetic field, which determines the magnetic force for small single-domain ferromagnetic particles, ranges from 100 T/m at the pole tip to a minimum of 10 Urn in an application volume of (20 mm)(3) and points inwardly to the center of the pole tip.